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Publication
Journal: European Journal of Medicinal Chemistry
December/5/2021
Abstract
Carbapenemases such as metallo-β-lactamases (MBLs) are spreading among Gram-negative bacterial pathogens. Infections due to these multidrug-resistant bacteria constitute a major global health challenge. Therapeutic strategies against carbapenemase producing bacteria include β-lactamase inhibitor combinations. Nitroxoline is a broad-spectrum antibiotic with restricted indication for urinary tract infections. In this study, we report on nitroxoline as an inhibitor of MBLs. We investigate the structure-activity relationships of nitroxoline derivatives considering in vitro MBL inhibitory potency in a fluorescence based assay using purified recombinant MBLs, NDM-1 and VIM-1. We investigated the most potent nitroxoline derivative in combination with imipenem against clinical isolates as well as transformants producing MBL by broth microdilution and time-kill kinetics. Our findings demonstrate that nitroxoline derivatives are potent MBL inhibitors and in combination with imipenem overcome MBL-mediated carbapenem resistance.
Keywords: Antibiotic resistance; Metal chelators; Metallo-β-lactamases; Nitroxoline.
Publication
Journal: Best Practice and Research in Clinical Obstetrics and Gynaecology
December/5/2021
Abstract
Strengthening the capacity of midwives and nurses in low- and middle-income countries to lead research is an urgent priority in embedding and sustaining evidence-based practice and better outcomes for women and newborns during childbearing. International and local travel restrictions, and physical distancing resulting from the COVID-19 pandemic have compromised the delivery of many existing programmes and challenged international partnerships working in maternal and newborn health to adapt rapidly. In this paper, we share the experiences of a midwife-led research partnership between Kenya, Malawi, Tanzania, Uganda, the UK, Zambia and Zimbabwe in sustaining and enhancing capacity strengthening activities remotely in this period. Whilst considerable challenges arose, and not all were overcome, collectively, we gained new insights and important learning which have shifted perspectives and will impact future design and delivery of learning programmes.
Keywords: COVID-19; Capacity strengthening; Global health; Midwifery; Nursing; Sub-saharan africa.
Publication
Journal: Trends in Molecular Medicine
December/5/2021
Abstract
Tumor blood vessels create optimal conditions for glioblastoma (GBM) growth and therapy resistance. Therefore, tissue engineering techniques evolved towards allowing its inclusion in preclinical in vitro GBM models. In comparison with conventional ones, less representative of tumor biology, these new tools might significantly improve GBM treatment, contributing to a higher throughput screening in drug research and to the clinical translation of these therapies.
Keywords: glioblastoma; in vitro models; neovascularization; perivascular niche; tissue engineering.
Publication
Journal: Best Practice and Research in Clinical Haematology
December/5/2021
Abstract
Leukemic transformation of myeloproliferative neoplasms (MPNs) is associated with dismal outcomes. The genetic complexity of leukemic transformation of MPNs is being deciphered and will likely result in targeted therapy approaches. Ongoing trials are investigating the efficacy of emerging treatments for this high-risk patient population. This review has outlined recent progress in the understanding and treatment of leukemia arising from MPNs.
Keywords: AML; Acute myeloid leukemia; Allo-HSCT; Allogeneic hematopoietic stem cell transplantation; CR; Complete remission; JAK2V617F; MPNs; Myeloproliferative neoplasms; OS; Overall survival; STK11; Serine threonine kinase 11; TP53.
Publication
Journal: Revue Neurologique
December/5/2021
Publication
Journal: Injury
December/5/2021
Publication
Journal: Fertility and Sterility
December/5/2021
Related with
Publication
Journal: Clinical Oncology
December/5/2021
Publication
Journal: Journal of the Formosan Medical Association = Taiwan yi zhi
December/5/2021
Related with
Publication
Journal: Wilderness and Environmental Medicine
December/5/2021
Abstract
Snakebite in India is often attributed to the "big 4," for which polyvalent anti-snake venom is effective. Also significant and less known is the burden of other venomous snakes, one of which is Trimeresurus malabaricus. We report a bite to the face of a tree climber by Trimeresurus malabaricus in the Western Ghats of India, which caused severe local envenomation in the form of facial edema and systemic signs of envenomation, including coagulopathy and hypotension. We discuss the role of thromboelastogram, infrared thermography, and routine diagnostics in this case, which led to the administration of Indian-made polyvalent anti-snake venom. The patient recovered and was discharged without any clinically evident physiological or physical dysfunction.
Keywords: Trimeresurus malabaricus; antivenom; envenomation; snakebite; thromboelastogram; venom induced consumptive coagulopathy.
Publication
Journal: Internal Medicine
December/5/2021
Abstract
With expansion of the COVID-19 pandemic, reports of post-COVID-19 interstitial lung disease (ILD) have been emerging. However, there are few reports regarding treatment. Some reports indicate that corticosteroids are effective for post-COVID-19 ILD, but the use of long-term corticosteroid carries risks of side effects. We administered tacrolimus to an elderly patient with post-COVID-19 ILD who suffered a respiratory failure relapse during steroid tapering. The respiratory status improved with tacrolimus in the post-acute phase, but pulmonary fibrosis progressed in the late phase. Tacrolimus may be effective for treating post-COVID-19 ILD in the post-acute phase, but it does not halt progression of pulmonary fibrosis.
Keywords: COVID19; Coronavirus disease 2019; immunosuppressive agent; interstitial lung disease; respiratory failure; tacrolimus.
Publication
Journal: Cardiology in the Young
December/5/2021
Abstract
A previously healthy 15-year-old teenage boy was admitted for fever and heart failure. Myocarditis was suspected, and endomyocardial biopsy revealed giant cell myocarditis. Immunosuppressive treatment was initiated, with excellent response. A plausible link to previous leptospirosis was identified. At 18-month follow-up, left ventricular function is normal. Only one other reported case of paediatric giant cell myocarditis had such a favourable outcome.
Keywords: Leptospira; Myocarditis; adolescent; giant cell myocarditis; heart failure.
Publication
Journal: Trends in Plant Science
December/5/2021
Abstract
Tef is a highly nutritious gluten-free Ethiopian cereal with food-feed potential. However, its productivity is affected by lodging, weed infestation, terminal drought, small seed size, and shattering. Following the recent availability of tef genome sequences, we highlight the need to harness the benefits that this underutilised crop offers to improve food security.
Keywords: Tef; cereal; gluten-free; livestock; nutrition; orphan crop.
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Publication
Journal: Trends in Plant Science
December/5/2021
Abstract
Genome sequences provide an unprecedented resource to rapidly develop modern crops. A recent paper by Varshney et al. provides genome variation maps of 3366 chickpea accessions. Here, we highlight how this breakthrough research can fundamentally change breeding practices of chickpea and potentially other crops.
Keywords: domestication; genetic gain; genome sequence; genomic selection; pangenome.
Publication
Journal: Journal of Invasive Cardiology
December/5/2021
Abstract
In this illustrative case, a transesophageal echocardiographic examination in a 69-year-old woman revealed normally functioning mechanical mitral prosthesis and a 4 cm left atrial heterogenous thrombus moving around her left atrium like a ping pong ball. Also visible was a thrombus within the left atrial appendage; the left atrial thrombus moved toward the mitral orifice and was bounced away by the mitral regurgitant jet.
Keywords: left atrial thrombus; transesophageal echocardiography.
Publication
Journal: Deutsches Ärzteblatt international
December/5/2021
Related with
Publication
Journal: Journal of Oleo Science
December/5/2021
Publication
Journal: Journal of Oleo Science
December/5/2021
Publication
Journal: Food Research International
December/5/2021
Abstract
There has been growing interest and substantial improvement in thermal processes for enhancing the heat transfer rate in food industry applications. The replacement of conventional heat transfer fluids with nanofluids is now being considered as a novel and emerging solution to the heat transfer problem of the food processing sector. This review covers state-of-the-art methods for production and application of these nanofluids with emphasis on the decontamination of liquid foods. The review also discusses the influence of processing conditions such as temperature and nanoparticle concentration on the thermal and viscous characteristics of the developed nanofluids. Further, the effect of these developed nanofluids on the quality attributes of food materials has also been reviewed and analyzed. Based on the current technological status, certain knowledge gaps in nanofluid research have been identified, including controlled (shape and size) and systematic experimental studies, stability of nanofluids with increasing thermal cycles, increasing the compatibility of base fluid to nanomaterials, and toxicity and environmental impact assessment.
Keywords: Enzymes; Food processes; Fruit and vegetable juice; Heat transfer; Microorganisms; Nanofluid synthesis; Toxicity.
Publication
Journal: American Journal of Surgery
December/5/2021
Abstract
Background: Technology-enhanced teaching and learning, including Artificial Intelligence (AI) applications, has started to evolve in surgical education. Hence, the purpose of this scoping review is to explore the current and future roles of AI in surgical education.
Methods: Nine bibliographic databases were searched from January 2010 to January 2021. Full-text articles were included if they focused on AI in surgical education.
Results: Out of 14,008 unique sources of evidence, 93 were included. Out of 93, 84 were conducted in the simulation setting, and 89 targeted technical skills. Fifty-six studies focused on skills assessment/classification, and 36 used multiple AI techniques. Also, increasing sample size, having balanced data, and using AI to provide feedback were major future directions mentioned by authors.
Conclusions: AI can help optimize the education of trainees and our results can help educators and researchers identify areas that need further investigation.
Keywords: Artificial intelligence; Assessment; Surgical education; Training.
Related with
Publication
Journal: Food Research International
December/5/2021
Abstract
The search for life/health quality has driven the search for a better understanding of food components on the overall individual health, which turns to be intrinsically related to the digestive system. In vitro digestion models are considered an alternative for the in vivo studies for a variety of practical reasons, but further research is still needed concerning the colon model establishment. An effective in vitro colon model should consider all unit operations and transport phenomena, together with chemical and biochemical reactions, material handling and reactor design. Due to the different techniques and dependence on the donor microbiota, it is difficult to obtain a standard protocol with results reproductible in time and space. Furthermore, the colon model should be fed with a representative substrate, thus what happens in upper digestion tract and absorption prior to colon is also of crucial importance. Essentially, there are two ways to think about how to achieve a good and useful in vitro colon model: a complex biomimetic system that provides results comparable with the in vivo studies or a simple system, that despite the fact it could not give physiologically relevant data, it is sufficient to understand the fate of some specific components.
Keywords: Biofilm; Colon; High-cell density; In vitro digestion; Solid-state fermentation; Transport phenomena.
Publication
Journal: Rinsho ketsueki] The Japanese journal of clinical hematology
December/5/2021
Abstract
Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic until today, but treatment options remain limited. COVID-19 vaccination is expected to decrease the number of patients with COVID-19 worldwide. In Japan, two types of mRNA COVID-19 vaccine, BNT162b2 (Pfizer/BioNTech) and mRNA-1273 (Moderna), have been approved and administered. However, their side effects remain poorly elucidated. This paper presents two cases of immune thrombocytopenia (ITP) after BNT162b2 mRNA COVID-19 vaccination. Whether or not ITP is triggered by the vaccination or not is difficult to identify. Further investigation with a large number of cases is warranted to clarify the side effects of BNT162b2 mRNA COVID-19 vaccination.
Keywords: COVID-19; Immune thrombocytopenia; SARS-CoV-2 vaccine.
Publication
Journal: Internal Medicine
December/5/2021
Abstract
A 54-year-old Japanese woman was admitted to our ward because of recurrent chest pain at rest for 2 months. She had been treated with nivolumab, an immune checkpoint inhibitor for inoperable advanced hypopharyngeal cancer for 21 months. She had no chest pain after cessation of nivolumab treatment. Cardiac catheterization confirmed the presence of vasospastic angina. Benidipine 8 mg was started, and she had no chest pain even after resuming therapy with nivolumab. Vasospastic angina is an adverse effect of nivolumab.
Keywords: adverse event; cancer; chest pain; oncology.
Publication
Journal: Seminars in Immunology
December/5/2021
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