Thrombotic thrombocytopenic purpura mimicking acute ischemic stroke.
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Journal: 2007/July - Emergency Medicine Journal
ISSN: 1472-0213
Abstract:
Thrombotic thrombocytopenic purpura (TTP) is an autoimmune disorder characterised by thrombocytopenia, haemolytic anemia, fluctuating neurological deficits, fever, and renal impairment. This case report is about a young man who presented with acute onset right sided paralysis, dysarthria, and central facial paralysis, suggestive of cerebrovascular accident, but eventually diagnosed as TTP. In addition, the clinical presentation of TTP is discussed and some teaching points for the emergency physicians are emphasised.
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Emerg Med J 23(9): e51
PMID: 16921072

Thrombotic thrombocytopenic purpura mimicking acute ischemic stroke

E Aksay, S Kiyan, M Ersel, Department of Emergency Medicine, Ege University Hospital, Izmir, Turkey
O Hudaverdi, Department of Internal Medicine, Ege University Hospital, Izmir, Turkey
Correspondence to: Dr E Aksay
Ege Universitesi Hastanesi, Acil Tıp Anabilim Dalı, 35100, Bornova, Izmir/TURKEY; ersin.aksay@ege.edu.tr
E Aksay, S Kiyan, M Ersel, Department of Emergency Medicine, Ege University Hospital, Izmir, TurkeyO Hudaverdi, Department of Internal Medicine, Ege University Hospital, Izmir, TurkeyCorrespondence to: Dr E Aksay
Ege Universitesi Hastanesi, Acil Tıp Anabilim Dalı, 35100, Bornova, Izmir/TURKEY; ersin.aksay@ege.edu.tr
Accepted 2006 Apr 16.
Copyright ©2006 Emergency Medicine Journal.

Abstract

Thrombotic thrombocytopenic purpura (TTP) is an autoimmune disorder characterised by thrombocytopenia, haemolytic anemia, fluctuating neurological deficits, fever, and renal impairment. This case report is about a young man who presented with acute onset right sided paralysis, dysarthria, and central facial paralysis, suggestive of cerebrovascular accident, but eventually diagnosed as TTP. In addition, the clinical presentation of TTP is discussed and some teaching points for the emergency physicians are emphasised.

Keywords: thrombotic thrombocytopenic purpura, emergency department, acute ischemic stroke, dysarthria
Abstract

Thrombotic thrombocytopenic purpura (TTP) is a rare disorder, and its clinical presentation mimics that of a variety of other diseases. Early diagnosis is important as TTP is a life threatening illness with mortality exceeding 90% in the absence of emergent, appropriate treatment.

Footnotes

Competing interests: none declared

Informed consent was obtained for publication of the person's details in this report.

Footnotes

References

  • 1. Sadler J E, Moake J L, Miyata T. et al Recent advances in thrombotic thrombocytopenic purpura. Hematology (Am Soc Hematol Educ Program) 2004407–423. [[PubMed]
  • 2. Vesely S K, George J N, Lammle B. et al ADAMTS13 activity in thrombotic thrombocytopenic purpura‐hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. Blood 200310260–68. [[PubMed]
  • 3. Peyvandi F, Ferrari S, Lavoretano S. et al von Willebrand factor cleaving protease (ADAMTS‐13) and ADAMTS‐13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura. Br J Haematol 2004127433–439. [[PubMed]
  • 4. Gurkan E, Baslamisli F, Guvenc B. et al Thrombotic thrombocytopenic purpura in southern Turkey: a single‐center experience of 29 cases.Clin Lab Haematol 200527121–125. [[PubMed]
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