Impressive Response to Capecitabine in a Patient with Obstructive Jaundice due to Metastatic Triple-Negative Breast Cancer.
Journal: 2019/September - Oncology Research and Treatment
ISSN: 2296-5262
PUBMED: 31557756
DOI: 10.1159/000502756
Abstract:Metastatic breast cancer with obstructive jaundice due to para-aortic lymph node enlargement is an unusual case that poses a therapeutic challenge in determining a chemotherapy regimen.A 61-year-old woman presented with triple-negative left invasive ductal breast carcinoma with liver and pulmonary metastases. After receiving gemcitabine and carboplatin as the 4th-line treatment, chemotherapy was postponed due to an increased bilirubin level. Abdominal imaging revealed para-aortic lymph node metastases compressing the distal common hepatic duct. The patient then received capecitabine along with ursodeoxycholic acid. This relieved her jaundice after 8 cycles of chemotherapy, and radiologic evaluation revealed a complete resolution of the obstructive jaundice.This finding emphasizes the success of capecitabine regimen as a salvage therapy in a metastatic breast cancer patient with hyperbilirubinemia and opens up the possibility of optimizing systemic chemotherapy for metastatic obstructive jaundice in the setting of limited facility resources.
Open in
Relations:
Diseases
(2)
Conditions
(3)
Drugs
(4)
Chemicals
(1)
Anatomy
(5)
Affiliates
(1)
Similar articles
Discussion board
Collaboration tool especially designed for Life Science professionals.Drag-and-drop any entity to your messages.
Search and select entities to see details here. Details will include lists of related entities (via publication). Explore related entities further.