Ginseng-Rhizome is the Rhizome of Panax ginseng and popularly named "Shenlu". The treatment group treated with the sugar-coated tablets of Ginseng-Rhizome saponin (GRS) orally for two months, one tablet (50 mg per tablet), three times a day. Through the clinical observations of 358 cases of middle and old age persons (age from 50 to 85 years old). The results showed that GRS possessed antisenility effect and marked effect on relieving the symptoms of aging, adjusting organic metabolism and improving physiological function, etc., such as promoting memory, raising the amount of white cells and improving organic immunity function. GRS both improved the function of hypophysisgonad axis and the function of adrenal cortex. It had marked efficacy in the treatment of coronary heart disease with angina pectoris and had better effect on treating concomitant atrial and ventricular prematures. The control group (123 cases, age from 50 to 85 years old) was given sugar-coated tablets of placebo (starch) for two months and then compared themselves with before. There were both no difference in clinical symptoms and experimental tests. After two years experimental researches and clinical observations, it showed that GRS tablet and Shenlu tablet both have no side effect of vomiting and also no toxic effect when they were taken for a long-term.