Abstract:

Ononitol monohydrate (OM) was isolated from Cassia tora L. leaves. The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice. The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic acid-induced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis. The analgesic activity of OM was assessed using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test. In acute type inflammation models, maximum inhibitions of 50.69 and 61.06% (P < .05) were noted with 20 mg/kg of OM in carrageenan-induced hind paw oedema and croton oil-induced ear oedema, respectively. Treatment of OM (20 mg/kg) meaningfully (P < .05) reduced the granuloma tissue formation by cotton pellet study at a rate of 36.25%. OM (20 mg/kg) inhibited 53.64% of paw thickness in adjuvant-induced arthritis model. OM has also been produced significant (P < .05) analgesic activity in acetic acid-induced abdominal constriction response, formalin-induced paw licking response and in hot-plate test suggesting its peripheral and central analgesic potential. The outcomes of the present study proposed that OM influenced on the anti-inflammatory and analgesic activities.

Open in

PUBMED | DOI | PMC | Google Scholar | Wikipedia

Relations:

Content

Citations

(1)

Drugs

(6)

Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from <em>Cassia tora</em> L. in animal models

Paulrayer Antonisamy

Muniyappan Dhanasekaran

^{Department of Korean Physiology, Wonkwang University School of Korean Medicine, 460 Iksan-daero, Iksan City, Jeonbuk 570−749, Republic of Korea}

^{Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai, Tamil Nadu, India}

^{Department of Plant Biology and Biotechnology, Loyola College, Chennai 600 034, Tamil Nadu, India}

Kang-Beom Kwon: rk.ca.ukw@nossed

^{Corresponding author.}rk.ca.ukw@nossed

^{These authors contributed equally to this work.}

Kang-Beom Kwon: rk.ca.ukw@nossed

Received 2017 Oct 20; Revised 2017 Nov 13; Accepted 2017 Nov 14.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Footnotes

Peer review under responsibility of King Saud University.

Footnotes

Collaboration tool especially designed for Life Science professionals.Drag-and-drop any entity to your messages.

Learn More