Acute lindane poisoning with development of muscle necrosis.
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Journal: 1977/December - CMAJ
ISSN: 0008-4409
PUBMED: 71942
Abstract:
A 35-year-old man ingested food contaminated with lindane, an insecticide containing almost pure gamma hexachlorocyclohexane. Grand mal seizures and severe acidemia developed rapidly. The seizures recurred for nearly 2 hours, then ceased. In addition, the patient had muscle weakness and pain, headaches, episodic hypertension, myoglobinuria, acute renal failure and anemia. Pancreatitis developed 13 days after the ingestion of lindane. A muscle biopsy on the 15th day of illness demonstrated widespread necrosis and regeneration of muscle fibres. The patient's condition improved and he was discharged 24 days after the onset of his illness. During the year following the poisoning the patient noted difficulty with recent memory, loss of libido and easy fatigability. One year after lindane ingestion the results of physical examination, including those for muscle power and bulk, were normal.
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Can Med Assoc J 117(9): 1050-1054
PMID: 71942

Acute lindane poisoning with development of muscle necrosis.

Abstract

A 35-year-old man ingested food contaminated with lindane, an insecticide containing almost pure gamma hexachlorocyclohexane. Grand mal seizures and severe acidemia developed rapidly. The seizures recurred for nearly 2 hours, then ceased. In addition, the patient had muscle weakness and pain, headaches, episodic hypertension, myoglobinuria, acute renal failure and anemia. Pancreatitis developed 13 days after the ingestion of lindane. A muscle biopsy on the 15th day of illness demonstrated widespread necrosis and regeneration of muscle fibres. The patient's condition improved and he was discharged 24 days after the onset of his illness. During the year following the poisoning the patient noted difficulty with recent memory, loss of libido and easy fatigability. One year after lindane ingestion the results of physical examination, including those for muscle power and bulk, were normal.

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Selected References

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  • Starr HG, Jr, Clifford NJ. Acute lindane intoxication: a case study. Arch Environ Health. 1972 Nov;25(5):374–375. [PubMed] [Google Scholar]
  • Czeglédi-Jankó G, Avar P. Occupational exposure to lindane: clinical and laboratory findings. Br J Ind Med. 1970 Jul;27(3):283–286.[PMC free article] [PubMed] [Google Scholar]
  • GILLIATT RW, SEARS TA. Sensory nerve action potentials in patients with peripheral nerve lesions. J Neurol Neurosurg Psychiatry. 1958 May;21(2):109–118.[PMC free article] [PubMed] [Google Scholar]
  • MAVOR H, LIBMAN I. Motor nerve conduction velocity measurement as a diagnostic tool. Neurology. 1962 Nov;12:733–744. [PubMed] [Google Scholar]
  • VAN ASPEREN K, OPPENOORTH FJ. Metabolism of gamma-benzene hexachloride in the animal body. Nature. 1954 May 22;173(4412):1000–1000. [PubMed] [Google Scholar]
  • Tolot F, Lenglet JP, Prost G, Bertholon J. Polynévrite due au lindane. J Med Lyon. 1969 May 5;50(164):747–754. [PubMed] [Google Scholar]
  • Dale WE, Curley A, Cueto C., Jr Hexane extractable chlorinated insecticides in human blood. Life Sci. 1966 Jan;5(1):47–54. [PubMed] [Google Scholar]
  • Hrdina PD, Singhal RL, Peters DA, Ling GM. Some neurochemical alterations during acute DDT poisoning. Toxicol Appl Pharmacol. 1973 Jun;25(2):276–288. [PubMed] [Google Scholar]
  • Koch RB. Chlorinated hydrocarbon insecticides: inhibition of rabbit brain ATPase activities. J Neurochem. 1969 Feb;16(2):269–271. [PubMed] [Google Scholar]
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Abstract
A 35-year-old man ingested food contaminated with lindane, an insecticide containing almost pure gamma hexachlorocyclohexane. Grand mal seizures and severe acidemia developed rapidly. The seizures recurred for nearly 2 hours, then ceased. In addition, the patient had muscle weakness and pain, headaches, episodic hypertension, myoglobinuria, acute renal failure and anemia. Pancreatitis developed 13 days after the ingestion of lindane. A muscle biopsy on the 15th day of illness demonstrated widespread necrosis and regeneration of muscle fibres. The patient's condition improved and he was discharged 24 days after the onset of his illness. During the year following the poisoning the patient noted difficulty with recent memory, loss of libido and easy fatigability. One year after lindane ingestion the results of physical examination, including those for muscle power and bulk, were normal.
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