Optimal duration of antibiotic therapy for uncomplicated urinary tract infection in older women: a double-blind randomized controlled trial

Thomas Vogel

René Verreault

Marie Gourdeau

Michèle Morin

Lise Grenier-Gosselin

Louis Rochette

From the Unité de recherche en gériatrie de l'Université Laval (Vogel, Verreault, Rochette), the Department of Infectious Diseases (Gourdeau) and the Department of Geriatrics (Morin), Centre hospitalier affilié universitaire de Québec, Québec, Que.; the Department of Social Preventive Medicine, Université Laval, Québec, Que. (Verreault); and the Department of Pharmacy, CLSC-CHSLD Basse-Ville-Limoilou-Vanier, Québec, Que. (Grenier-Gosselin)

Abstract

Background

The optimal duration of antibiotic therapy in older patients with uncomplicated urinary tract infection (UTI) is still a matter of debate. The aim of this randomized controlled double-blind noninferiority trial was to compare the efficacy and safety of 3-day and 7-day courses of oral ciprofloxacin for uncomplicated symptomatic UTI in older women.

Methods

A total of 183 women at least 65 years of age with acute uncomplicated UTI were recruited from ambulatory clinics and hospital acute care units. Patients with pyelonephritis, contraindications to fluoroquinolones, recent use of antibiotics, urinary tract abnormalities and diabetes mellitus were excluded. Women were randomly assigned to receive either ciprofloxacin 250 mg twice daily orally for 3 days followed by placebo for 4 days (the 3-day group, 93 patients) or ciprofloxacin 250 mg twice daily orally for 7 days (the 7-day group, 90 patients). Bacterial eradication, clinical improvement and occurrence of adverse events were determined 2 days after completion of treatment, and occurrence of reinfection or relapse were determined 6 weeks after completion of treatment. Bacterial eradication and relapse were determined by urine culture. Double-blind procedures were maintained throughout data collection.

Results

The proportion of patients with bacterial eradication at 2 days after treatment was 98% (91/93) in the 3-day group and 93% (83/89) in the 7-day group (p = 0.16). The frequency of adverse events, including drowsiness, headache, nausea or vomiting, and loss of appetite, was significantly lower in the 3-day group.

Interpretation

These results suggest that a 3-day course of antibiotic therapy is not inferior to a 7-day course for treatment of uncomplicated symptomatic UTI in older women, and that the shorter course is better tolerated.

Abstract

Acknowledgments

This work was supported by a grant from the Fonds de la recherche en santé du Québec (grant 961464-104). René Verreault was supported by a grant from the Chaire de gériatrie de l'Université Laval.

Acknowledgments

Footnotes

This article has been peer reviewed.

Contributors: René Verreault was responsible for project conception, protocol development and data collection; he also contributed to the statistical analyses and to the writing and revision of the manuscript. Thomas Vogel was responsible for the statistical analyses, writing and revisions. Marie Gourdeau, Michèle Morin and Lise Grenier-Gosselin contributed to protocol development, writing and revisions. Louis Rochette contributed to the statistical analyses, writing and revisions.

Competing interests: None declared.

Correspondence to: René Verreault, Unité de recherche en gériatrie de l'Université Laval, Hôpital du St-Sacrement, Bureau L2–26, 1050, chemin Sainte-Foy, Québec QC G1S 4L8; fax 418 682–7998;ac.lavalu.psm@tluaerreV.eneR

Footnotes

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