Abstract:

In the study, we evaluated chemical composition and antimicrobial, antibiofilm, and antitumor activities of essential oils from dried leaf essential oil of leaf and flower of Agastache rugosa for the first time. Essential oil of leaf and flower was evaluated with GC and GC-MS methods, and the essential oil of flower revealed the presence of 21 components, whose major compounds were pulegone (34.1%), estragole (29.5%), and p-Menthan-3-one (19.2%). 26 components from essential oil of leaf were identified, the major compounds were p-Menthan-3-one (48.8%) and estragole (20.8%). At the same time, essential oil of leaf, there is a very effective antimicrobial activity with MIC ranging from 9.4 to 42 μg ml(-1) and potential antibiofilm, antitumor activities for essential oils of flower and leaf essential oil of leaf. The study highlighted the diversity in two different parts of A. rugosa grown in Xinjiang region and other places, which have different active constituents. Our results showed that this native plant may be a good candidate for further biological and pharmacological investigations.

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Antimicrobial, antibiofilm and antitumor activities of essential oil of <em>Agastache rugosa</em> from Xinjiang, China

^{The Fifth Affiliated Hospital of Xinjiang Medical University, Xinshi District, No. 118 Henan Westroad, Urumqi, Xinjiang, PR China}

^{Xinjiang Medical University, Xinshi District, No. 393 Xinyi Road, Urumqi, Xinjiang, PR China}

^{The Third Affiliated Hospital of Xinjiang Medical University, Xinshi District, No. 789 Suzhou Eestroad, Urumqi, Xinjiang, PR China}

^{Faculty of Science and Natural Resources, University Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia}

Zhang Chen: moc.liamg@2ilgnimuz

^{Corresponding author. Tel.: +86 15981757393; fax: +86 0991 7557459.}moc.liamg@2ilgnimuz

Zhang Chen: moc.liamg@2ilgnimuz

Received 2015 Nov 13; Revised 2016 Jan 27; Accepted 2016 Feb 17.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Peer review under responsibility of King Saud University.

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