Abstract:

Objective: To analyze the blood test indicators of patients after infection of COVID-19 in Chongqing and analyze the clinical indicators of 8 patients with diarrhea. Materials and Methods: From January 26, 2019 to February 13, 2020, 70 patients diagnosed with 2019-nCoV according to the World Health Organization interim guidance for NCP and divided into diarrhea and non-diarrhea groups. The laboratory tests liver and kidney function, blood routine, coagulation function, and immune status. Results: The study population included 70 hospitalized patients with confirmed CONV-2019. NCP patients (43males and 27 females) with a mean age of 48.57±17.80 (9~82) years and only 4.3% of patients have lung-related diseases. The positive rate of ESR, CRP, PT, IL6, lymphocyte count, GGT, Prealbumin and CD4 was more than 50%. We further analyzed the differences between 8 diarrhea patients and 62 non-diarrhea patients. Among these indicators, only Lymphocyte, CRP, Prealbumin and Cystatin C positive rate is more than 50%. Although there is no statistical difference in GGT, 100% of the 7 patients tested decreased. Conclusion: Our data recommended that the ESR, CRP, PT, IL6, lymphocyte count, GGT, prealbumin and CD4 have important value in the diagnosis of COVID-19, and the decrease of GGT may be an important indicator for judging the intestinal dysfunction of patients.

Keywords: COVID-19; Diarrhea; GGT; Peripheral blood.

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Characteristics of in peripheral blood of 70 hospitalized patients and 8 diarrhea patients with COVID-19

^{Department of Infectious Diseases, Yongchuan Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.}

^{Cancer center, Daping Hospital, The Third Military Medical University, Yuzhong District, Chongqing 400042, P.R. China.}

^{Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.}

^{Chongqing Yongchuan District Center for Disease Control and Prevention, Chongqing 400016, P.R. China.}

✉ Corresponding authors: Wen-Guang Tian, E-mail: moc.361@6639gwt.; Wen-Xiang Huang, E-mail:moc.liamtoh@gnauh_gnaixnew.

#These authors contributed equally to this work.

Competing Interests: The authors have declared that no competing interest exists.

Received 2020 Mar 7; Accepted 2020 Apr 28.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

Abstract

Objective: To analyze the blood test indicators of patients after infection of COVID-19 in Chongqing and analyze the clinical indicators of 8 patients with diarrhea.

Materials and Methods: From January 26, 2019 to February 13, 2020, 70 patients diagnosed with 2019-nCoV according to the World Health Organization interim guidance for NCP and divided into diarrhea and non-diarrhea groups. The laboratory tests liver and kidney function, blood routine, coagulation function, and immune status.

Results: The study population included 70 hospitalized patients with confirmed CONV-2019. NCP patients (43males and 27 females) with a mean age of 48.57±17.80 (9~82) years and only 4.3% of patients have lung-related diseases. The positive rate of ESR, CRP, PT, IL6, lymphocyte count, GGT, Prealbumin and CD4 was more than 50%. We further analyzed the differences between 8 diarrhea patients and 62 non-diarrhea patients. Among these indicators, only Lymphocyte, CRP, Prealbumin and Cystatin C positive rate is more than 50%. Although there is no statistical difference in GGT, 100% of the 7 patients tested decreased.

Conclusion: Our data recommended that the ESR, CRP, PT, IL6, lymphocyte count, GGT, prealbumin and CD4 have important value in the diagnosis of COVID-19, and the decrease of GGT may be an important indicator for judging the intestinal dysfunction of patients.

Keywords: Peripheral blood, COVID-19, GGT, Diarrhea

A: Wuhan infected people; B: Infecting people in Chongqing.

Note: a: high vs normal, b: low vs normal.

Acknowledgments

The study was supported by Chongqing Medical University New Coronary Virus Pneumonia Disease Progression and Prognosis Model Establishment Project (20200212-10).

The data availability statement

All data gathered and included in the present study are available and can be provided by the corresponding author upon reasonable request.

Ethics approval

This study was approved by the ethical committee of Yongchuan Hospital of Chongqing Medical University and informed consent was obtained from each patient.

References

1. Huang C, Wang Y, Li X. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506.
2. Chen N, Zhou M, Dong X. et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–513.
3. CfDCa PInterim Guidelines for Collecting, Handling, and Testing Clinical Specimens from Persons Under Investigation (PUIs) for Coronavirus Disease 2019 (COVID-19) Interim Guidelines for Collecting, Handling, and Testing Clinical Specimens from Persons Under Investigation (PUIs) for Coronavirus Disease 2019 (COVID-19). https://www.cdc.gov/coronavirus/2019-ncov/lab/guidelines-clinical-specimens.html. 2020. [Google Scholar]
4. CNH Cthe Novel Coronavirus Pneumonia Prevention and Control guideline. http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml. 2020. [Google Scholar]
5. Wang D, Hu B, Hu C, Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020.

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