Extensive clinical investigation was accomplished to study the influence of three antibacterial preparations groups (tetracyclines, aminoglycosides and fluorochinolons) on the phagocytic-macrophages and the immune systems in patients, to whom transurethral local microwave hyperthermia (TLMH) of prostate was performed for its benign hyperplasia. The data obtained witness high efficacy of fluorochinolons group preparation (tavanic) toward bacteria of different nosologic groups, as well as to their atypical forms. Pronounced efficacy and simplicity of application of the preparation had allowed to recommend its wide use in urologic practice.