Anticancer Effect of New Cannabinoids Derived from Tetrahydrocannabinolic Acid on PANC-1 and AsPC-1 Human Pancreas Tumor Cells
Abstract
Purpose: New tetrahydrocannabinolic acid (THCA) derivatives ALAM027 and ALAM108 were proposed for the treatment of the pancreatic cancer disease.
Methods: The in vitro effect of new cannabinoids ALAM027 and ALAM108 was tested against PANC-1 and AsPC-1 cell lines by CellTiter Glo assay. Pancreatic cancer xenograft model was used for the in vivo anticancer activity study of these compounds on PANC-1 cells.
Results: The in vitro study of new cannabinoids showed greater activity of ALAM108 than ALAM027 both for PANC-1 and AsPC-1 cells. The in vivo study of new cannabinoids on PANC-1 cells showed that their oral administration was effective in reducing tumor volume and tumor weight, and did not lead to any discomfort and weight loss of mice.
Conclusion: The cannabinoids ALAM108 and ALAM027 inhibited the tumor growing 1.6–2 times in mice with human PANC-1 cells.
Acknowledgments
The author thanks the employees of Shanghai Chempartner (China) and Pharmaseed Ltd. (Israel) for their high professionalism and attention in this study.
Abbreviations Used
| GC | gemcitabine |
| NPT | nab-paclitaxel |
| RT | room temperature |
| THC | tetrahydrocannabinol |
| THCA | tetrahydrocannabinolic acid |
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