Targeted delivery of Colloidal Silver for MCF-7 Breast Cancer Treatment.

Journal: 2020/May - Current Drug Delivery

ISSN: 1875-5704

DOI: 10.2174/1567201817666200508095241

Abstract:

Amongst various cancer diseases, breast cancer is frequently diagnosed malignancy in women. Existing treatments are inadequate, painful and toxic. New ways of treatments need to be explored.The present work proposes preparation and targeted delivery of a formulation, F-1, for MCF-7 breast cancer treatment. The formulation, colloidal silver (0.76 ppm), was prepared by electrolytic deposition technique and multi surface coatings. Black tea extract (2.25%v/v) was used as capping agent to tune morphology of silver nanoparticle and potato extract (6.25%v/v) as functionalizing agent for targeting MCF-7 breast cancer site.Characterization results show highly pure spherical silver nanoparticles with an average particle size of 15nm. Shift of peaks in FTIR spectra of formulation confirm interaction between nanoparticles and extracts. The UV-visible peak was obtained at 525nm, typical characteristic of silver nanoparticles. In-vivo anti-cancer study of formulation gave moderate therapeutic effect in Non-obese diabetic severe combined immune deficiency (NOD-SCID) mice.It is observed that tumor volumes obtained in case of Formulation-1 were moderately inhibited from days 5 to 9. However, one of the mice in Formulation-1 group inhibited tumor volume to 1.52 cc similar to one of the mice of positive control group (Adriamycin 1.42cc).

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