OBJECTIVE

To study the chemical constituents in the root of Cocculus orbiculatus var. mollis.

METHODS

The compounds were isolated by silica gel chromatography, their structures were established by spectroscopic methods.

RESULTS

Eleven compounds were isolated and identified as wattisine A (I), O-methylcocsoline (II), (+) cocsoline (III), (+) cocsuline (IV), magnoflorine (V), sino-coculine (VI), isosinococuline (VII), (-) coclaurine (VIII), daucosterol (IX), beta-sitosterol (X) and 1-oleioyl-3-(9Z, 12Z-arachoyl) glycerol (XI).

CONCLUSIONS

Compound I is isolated from this genus for the first time,and compound II - XI are isolated from this plant for the first time.