Paraneoplastic opsoclonus-myoclonus syndrome as a presentation of high grade serous ovarian cancer.
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Journal: 2019/December - Gynecologic Oncology Reports
ISSN: 2352-5789
Abstract:
Opsoclonus-myoclonus syndrome (OMS) is a rare paraneoplastic disorder that is most often seen in association with pediatric neuroblastoma, breast cancer, small cell lung cancer, and prostate cancer. There are only three previously documented cases relating paraneoplastic OMS to ovarian cancer. We present a unique case of OMS related to a stage IIIC high grade serous ovarian carcinoma in a patient with germline BRCA2 mutation, with ten years of clinical follow up. This case report is presented to document the rare association of OMS with epithelial ovarian cancer. Additionally, in this case, OMS and epithelial cancer were successfully treated with medical therapy alone. This is the first report to our knowledge to document ten years of clinical follow up in this context, and to report that the association may not be evident at the time of ovarian cancer recurrence.
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Gynecol Oncol Rep 30: 100511
PMID: 31828196

Paraneoplastic opsoclonus-myoclonus syndrome as a presentation of high grade serous ovarian cancer

Declaration of Competing Interest

The authors declare no conflict of interest related to this case report.

University of British Columbia, Division of Gynecologic Oncology, Canada
Kimberly T. Stewart: ac.cbu.inmula@trawets.ylrebmiK
Corresponding author at: University of British Columbia, Division of Gynecologic Oncology, 6th Floor Gynecology, 2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada. ac.cbu.inmula@trawets.ylrebmiK
Received 2019 Aug 6; Revised 2019 Oct 9; Accepted 2019 Oct 13.
Copyright © 2019 The Author(s)
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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