HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana.
Journal: 1996/September - Journal of Natural Products
ISSN: 0163-3864
PUBMED: 8778237
DOI: 10.1021/np960250m
Abstract:
Bioassay-directed fractionation of the CH2Cl2-MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3-5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 microM, respectively), but 3-5 were inactive against HIV-1.
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