Fatigue, Sleep Disturbances, and Their Influence on Quality of Life in Cervical Dystonia Patients.
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Journal: 2018/November - Movement Disorders Clinical Practice
ISSN: 2330-1619
Abstract:
UNASSIGNED
Nonmotor symptoms (NMS) are highly prevalent in cervical dystonia (CD). In general, fatigue and sleep are important NMS that determine a decreased health-related quality of life (HR-QoL), but their influence in CD is unknown. The authors systematically investigated fatigue, excessive daytime sleepiness (EDS), and sleep quality in patients with CD and controls and assessed the influence of psychiatric comorbidity, pain, and dystonia motor severity. They also examined the predictors of HR-QoL.
UNASSIGNED
The study included 44 patients with CD and 43 matched controls. Fatigue, EDS, and sleep quality were assessed with quantitative questionnaires and corrected for depression and anxiety using analysis of covariance. The Toronto Western Spasmodic Torticollis Rating Scale and the Clinical Global Impression Scale-jerks/tremor subscale were used to score motor severity and to assess whether motor characteristics could explain an additional part of the variation in fatigue and sleep-related measures. HR-QoL was determined with the RAND-36 item Health Survey, and predictors of HR-QoL were assessed using multiple regression.
UNASSIGNED
Fatigue scores were increased independently from psychiatric comorbidity (4.0 vs. 2.7; P < 0.01), whereas EDS (7.3 vs. 7.4; P = 0.95) and sleep quality (6.5 vs. 6.1; P = 0.73) were highly associated with depression and anxiety. In patients with CD, motor severity did not explain the variations in fatigue (change in the correlation coefficient [ΔR2] = 0.06; P = 0.15), EDS (ΔR2 = 0.00; P = 0.96), or sleep quality (ΔR2 = 0.04; P = 0.38) scores. Fatigue, EDS, psychiatric comorbidity, and pain predicted a decreased QoL.
UNASSIGNED
Independent from psychiatric comorbidity and motor severity, fatigue appeared to be a primary NMS. Sleep-related measures were highly associated with psychiatric comorbidity, but not with motor severity. Only NMS predicted HR-QoL, which emphasizes the importance of attention to NMS in patients with CD.
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Mov Disord Clin Pract 4(4): 517-523
PMID: 30363425

Fatigue, Sleep Disturbances, and Their Influence on Quality of Life in Cervical Dystonia Patients

Supporting information

Table S1. The effect of psychoactive medication on FSS, ESS, and PSQI scores

Table S2. Influence of motor symptom severity on the FSS, ESS, and PSQI

Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands,
Department of Neurology, Ommelander Hospital Group, Delfzijl, the Netherlands,
Department of Neurology, Safarik University, Kosice, Slovakia,
Department of Neurology, University Hospital L. Pasteur, Kosice, Slovakia,
Department of Health Sciences, Community and Occupational Medicine, University Medical Center Groningen, Groningen, the Netherlands,
Department of Neuroscience, University Medical Center Groningen, Groningen, the Netherlands,
Marina A. Tijssen, Email: ln.gcmu@nessjit-gninok.ed.j.a.m.
Corresponding author.
Correspondence to: Dr. Marina A. Tijssen, Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9700RB Groningen, the Netherlands; E‐mail: ln.gcmu@nessjit-gninok.ed.j.a.m
Received 2016 Jul 13; Revised 2016 Sep 13; Accepted 2016 Oct 26.
Copyright © 2016 International Parkinson and Movement Disorder Society
Click here for additional data file.(14K, docx)Click here for additional data file.(14K, docx)

Notes

Relevant disclosures and conflicts of interest are listed at the end of this article.

Supporting information may be found in the online version of this article.

Notes

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