For people unaccustomed to high altitude, exposure to height often leads to Acute Mountain Sickness, with headaches, difficulty breathing and gastrointestinal symptoms. Nausea and loss of appetite may result in less calorie intake and weight loss. At altitudes greater than 4000 m about 50-80% of people are affected. After only short exposure, gastrointestinal mucosal lesions can occur, potentially leading to gastrointestinal bleeding and lessened hunger. Patients with inflammatory bowel disorders may develop an acute exacerbation. At high altitude, an induction of numerous metabolic processes can be observed, including increased iron absorption. While the pathophysiology of hypobaric hypoxia has been well documented for the respiratory and cardiovascular system, this Mini-Review summarizes the current literature concerning the gastrointestinal function in high altitude.