Three depsidones boremexins A-C (1-3), two diaryl ethers boremexins D (4) and E (5), together with four known compounds were obtained from cultures of potato endophytic fungus Boeremia exigua. Their structures with absolute configurations were established by extensive spectroscopic methods and electronic circular dichroism (ECD) calculations. Compounds 1-4, 6, and 9 displayed anti-inflammatory properties on nitric oxide production in LPS-induced RAW264.7 macrophages with an IC₅₀ range of 19.4-34.4 μM. Compounds 2 and 5 exhibited cytotoxicities to human breast cancer cell line (MCF-7) with IC₅₀ values of 33.1 and 4.0 μM, respectively.