In the present work the photocatalytic and biological degradation of two commercial mixtures of pesticides (Folimat and Ronstar) and two fungicides (pyrimethanil and triadimenol) has been studied. The evolution of some components of these commercial products (dicofol, tetradifon and oxadiazon) and that of the two fungicides has been monitored by means of HPLC, GC-MS, TOC and toxicity (Lemna minor toxicity test) measurements. The photocatalytic method was able to degrade dicofol, tetradifon, pyrimethanil, triadimenol and the components of Ronstar with the exception of oxadiazon. In addition to this, the photocatalytic method eliminated pyrimethanil toxicity and reduced that of triadimenol by a 90%, Ronstar by a 78% and Folimat by an 87%. Nevertheless, the wetland reactors alone could reduce the toxicity of only the former. Finally, the proper dosage of the water containing the pesticides to a photocatalytic reactor followed by a wetland reactor resulted to be the most successful strategy for the detoxification of the studied compounds and their mixtures.