Br J Pharmacol 45(2): 322-332
The anti-inflammatory effect of catecholamines in the peritoneal cavity and hind paw of the mouse
Abstract
1. Carrageenin or 5-hydroxytryptamine-induced oedema of the mouse hind paw was antagonized by catecholamines acting on both α- and β-adrenoceptors.
2. Increased permeability of the mouse peritoneum induced by the local injection of acetic acid or pro-inflammatory mediators was antagonized by catecholamines acting predominantly on β-adrenoceptors.
3. The anti-inflammatory effect of catecholamines was due neither to hyperglycaemia nor to the release of adrenal cortical hormones.
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Selected References
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