Br J Clin Pharmacol 15(Suppl 2): 295S-298S
Antidepressant drugs, convulsions and epilepsy
Abstract
1 Evidence concerning the convulsant effects of non-monoamine oxidase inhibitor antidepressant drugs has been reviewed.
2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose.
3 The convulsant effects of mianserin are probably no greater than for other non-monoamine oxidase inhibitor antidepressant drugs.
4 Enzyme-inducing anti-epileptic drugs can reduce the peak plasma concentration of mianserin and shorten its elimination half-life, probably by inducing its metabolism.
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