Non-nutritive Sweeteners and Their Associations with Obesity and Type 2 Diabetes

Department of Health, Human Performance, and Recreation, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, USA

^{Corresponding author} Yunsuk Koh, https://orcid.org/0000-0001-9280-5786, Department of Health, Human Performance, and Recreation, Robbins College of Health and Human Sciences, Baylor University, One Bear Place #97313, Waco, TX 76798, USA, Tel: +1-254-710-4002, Fax: +1-254-710-3527, E-mail: ude.rolyab@hok_kusnuy

Received 2019 Dec 19; Revised 2020 Feb 18; Accepted 2020 Apr 9.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Evidence linking the excessive consumption of nutritive sweeteners (NS) to adverse metabolic health outcomes has led to an increase in consumption of non-nutritive sweeteners (NNS), particularly among the obese and individuals with diabetes. NNS are characterized by having zero-to-negligible caloric load, while also having a sweet taste. They are utilized as a replacement for traditional NS to reduce energy intake and to limit carbohydrate-related negative health outcomes. However, recent studies have suggested that NNS may actually contribute to the development or worsening of metabolic diseases, including metabolic syndrome, obesity, type

2 diabetes, and cardiovascular disease. Thus, it is imperative to understand the NNS efficacy and the relationship between NNS and metabolic diseases.

Keywords: Stevia, Diabetes, Aspartame, Sucralose, Glucose, Obesity

Abstract

Footnotes

CONFLICTS OF INTEREST

The authors declare no conflict of interest.

AUTHOR CONTRIBUTIONS

Study concept and design: all authors; drafting of the manuscript: all authors; critical revision of the manuscript: YK; and study supervision: YK.

Footnotes

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