Despite there being a number of excellent studies on detoxification enzyme-mediated interaction between insect and plant allelochemical, there are no reports on the pathway of the transferrin effect in insect response to host plant allelochemical. Our research indicates that Helicoverpa armigera transferrin (HaTrf) inhibited the apoptotic cell death treated by 2-tridecanone, a host plant allelochemical present in tomato species (Lycopersicon hirsutum f. glabratum), by cellular redox-related transcription factor nuclear factor erythroid-2-related factor 2 (Nrf2). Nrf2 can defend organisms against the detrimental effects of oxidative stress and play pivotal roles in preventing host plant allelochemical-related toxicity. This study explains how HaTrf inhibited the apoptotic cell death during exposure to host plant allelochemical 2-tridecanone and provides a novel view on transferrin and its anti-apoptotic role in plant-insect interactions.

Keywords: 2-tridecanone; Helicoverpa armigera; cis-acting element; host plant allelochemical; nuclear factor erythroid-2-related factor 2; transferrin.