Serum lipoprotein (alpha) [Lp(alpha)]was determined in 105 cases of myocardial infarction survivors (MIS). Lp(alpha) level in MIS was much more elevated as compared with that in healthy subjects and in a hypertension group. Lp(alpha) had no relation with apolipoprotein B and AI, cholesterol, triglyceride and high density lipoprotein cholesterol. It may be a significant and independent risk factor for coronary heart disease.