OBJECTIVE

To study the anticancer activity of the Clematis manshrica saponins in vivo.

METHODS

Anticancer activities were tested in mice with experimental tumor (S180, HepA and P388) in vivo.

RESULTS

The Clematis manshrica saponins showed a significant anticancer activities on Sarcoma-180, HepA and P388 implanted in mice. In S180 sarcoma, the average tumor inhibition rates were 42.78%, 52.06% and 58.25% (P < 0.05-0.01) respectively; The mean inhibition rates were 37.44%, 52.05% and 59.36% (P < 0.05-0.001) in Hep A tumor separately; while in P388 tumor, the mean inhibition rates were 34.50%, 46.78% and 54.39% (P < 0.05-0.01), respectively.

CONCLUSIONS

The results indicate that Clematis manshrica has obvious antitumor effects against various transplanted tumor in mice.