Stepping up Th1 immunity to control phagosomal bacteria
Journal: 2021/May - Trends in Immunology
Abstract:
How does the immune system tailor effector function to particular threats? Krueger et al. reveal that infection with Salmonella enterica (SE), but not with influenza A virus (IAV), drives interleukin (IL)-12-dependent outgrowth of interferon (IFN)-γhi type 1 T helper (Th1) cells, leading to superior protection against this phagosomal pathogen. Among these cells are ZEB2-dependent cytotoxic Th1 cells marked by CX3CR1 expression.
Keywords: CX3CR1; IL-12; T helper cells; ZEB2; cytotoxic CD4 T cells; phagosomal pathogens.
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