Aging Med (Milton) 3(1): 48-52
PMC: PMC7099748
doi: 10.1002/agm2.12095
Pancreatic senescence and its clinical manifestations
Songbai Zheng, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Email: moc.361@9001iabgnos,
Notes
Wang L, Zheng S. Pancreatic senescence and its clinical manifestations. Aging Med. 2020;3:48–52. 10.1002/agm2.12095 [CrossRef] [Google Scholar]
References
- 1. Stamm BH. Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease. Hum Pathol. 1984;15(7):677‐683. [[PubMed]
- 2. Caglar V, Songur A, Yagmurca M, et al. Age‐related volumetric changes in pancreas: a stereological study on computed tomography. Surg Radiol Anat. 2012;34(10):935‐941. [[PubMed]
- 3. Janssen J, Papavassiliou I. Effect of aging and diffuse chronic pancreatitis on pancreas elasticity evaluated using semiquantitative EUS elastography. Ultraschall in der Medizin. 2014;35(3):253‐258. [[PubMed]
- 4. Sato T, Ito K, Tamada T, et al. Age‐related changes in normal adult pancreas: MR imaging evaluation. Eur J Radiol. 2012;81(9):2093‐2098. [[PubMed]
- 5. Anand BS, Vij JC, Mac HS, et al. Effect of aging on the pancreatic ducts: a study based on endoscopic retrograde pancreatography. Gastrointest Endosc. 1989;35(3):210‐213. [[PubMed]
- 6. Hastier P, Buckley MJ, Dumas R, et al. A study of the effect of age on pancreatic duct morphology. Gastrointest Endosc. 1998;48(1):53‐57. [[PubMed]
- 7. Glaser J, Stienecker K. Pancreas and aging: A study using ultrasonography. Gerontology. 2000;46(2):93‐96. [[PubMed]
- 8. Riccillo FL, Bracamonte MI, Console GM, et al. Histomorphological and quantitative immunohistochemical changes in the rat pancreas during aging. Biocell. 2004;28:127‐134. [[PubMed]
- 9. Detlefsen S, Sipos B, Feyerabend B, et al. Pancreatic fibrosis associated with age and ductal papillary hyperplasia. Virchows Archiv. 2005;447(5):800‐805. [[PubMed]
- 10. Gupta R, Kumar NA. Morphology and aging of the human adult pancreas: an electron microscopic study. Acta Medica Iranica. 2018;56:106‐112. [PubMed]
- 11. Kehm R, Konig J, Nowotny K, et al. Age‐related oxidative changes in pancreatic islets are predominantly located in the vascular system. Redox Biol. 2018;15: 387‐393.
- 12. Saisho Y, Butler AE, Manesso E, et al. Response to Comment on: Saisho et al. beta‐cell mass and turnover in humans: effects of obesity and aging. Diabetes Care 2013;36:111‐117. Diabetes Care. 2013;36(7):e112.
- 13. Chen Q, Li LQ, Chen SQ. Changes of ultrastructure of pancreas and distribution of islets in aged rats. Sichuan Anat J. 2005;13(2):11‐14. [PubMed]
- 14. Reaven EP, Reaven GM. Structure and function changes in the endocrine pancreas of aging rats with reference to the modulating effects of exercise and caloric restriction. J Clin Investig. 1981;68(1):75‐84.
- 15. Wang S, Sun QQ, Xiang B, et al. Pancreatic islet cell autophagy during aging in rats. Clin Invest Medet experimentale. 2013;36(2):E72‐E80. [[PubMed]
- 16. Gu Z, Du Y, Liu Y, et al. Effect of aging on islet beta‐cell function and its mechanisms in Wistar rats. Age. 2012;34(6):1393‐1403.
- 17. Wang S, Li J, Li XJ, et al. Morphological function of pancreatic beta cells in aged SD rats. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39(2):197‐201. [[PubMed]
- 18. Muller DC, Elahi D, Tobin JD, et al. Insulin response during the oral glucose tolerance test: the role of age, sex, body fat and the pattern of fat distribution. Aging. 1996;8(1):13‐21. [[PubMed]
- 19. Ihm SH, Moon HJ, Kang JG, et al. Effect of aging on insulin secretory function and expression of beta cell function‐related genes of islets. Diabetes Res Clin Pract. 2007;77(Suppl. 1):S150‐S154. [[PubMed]
- 20. Perfetti R, Wang Y, Shuldiner AR, et al. Molecular investigation of age‐related changes in mouse endocrine pancreas. J Gerontol Series A Biol Sci Med Sci. 1996;51(5):B331‐B336. [[PubMed]
- 21. Ammon HP, Fahmy A, Mark M, et al. The effect of glucose on insulin release and ion movements in isolated pancreatic islets of rats in old age. J Physiol. 1987;384:347‐354.
- 22. Tokuyama T, Yagui K, Yamaguchi T, et al. Expression of human islet amyloid polypeptide/amylin impairs insulin secretion in mouse pancreatic beta cells. Metab Clin Exp. 1997;46(9):1044‐1051. [[PubMed]
- 23. Rothenbacher D, Low M, Hardt PD, et al. Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population‐based study. Scand J Gastroenterol. 2005;40(6):697‐704. [[PubMed]
- 24. Hedström A, Haas SL, Berger B, et al. Frequency of exocrine pancreatic insufficiency in 1105 patients with gastrointestinal symptoms. Pancreatology. 2015;15(3 Suppl.):S74. [PubMed]
- 25. Herzig KH, Purhonen AK, Rasanen KM, et al. Fecal pancreatic elastase‐1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus. BMC Geriatr. 2011;11:4.
- 26. Torigoe T, Ito K, Yamamoto A, et al. Age‐related change of the secretory flow of pancreatic juice in the main pancreatic duct: evaluation with cine‐dynamic MRCP using spatially selective inversion recovery pulse. AJR Am J Roentgenol. 2014;202(5):1022‐1026. [[PubMed]
- 27. Ishibashi T, Matsumoto S, Harada H, et al. Aging and exocrine pancreatic function evaluated by the recently standardized secretin test. Nihon Ronen Igakkai Zasshi. 1991;28(5):599‐605. [[PubMed]
- 28. Laugier R, Bernard JP, Berthezene P, et al. Changes in pancreatic exocrine secretion with age: pancreatic exocrine secretion does decrease in the elderly. Digestion. 1991;50(3–4):202‐211. [[PubMed]
- 29. Bulow R, Simon P, Thiel R, et al. Anatomic variants of the pancreatic duct and their clinical relevance: an MR‐guided study in the general population. Eur Radiol. 2014;24(12):3142‐3149. [[PubMed]
- 30. Geriatric Gastroenterology Group , Geriatric Society , Chinese Medical Association . Consensus of Chinese experts on the application of digestive enzymes in elderly dyspepsia. Chin J Geriatr. 2018;37(6):605‐611. [PubMed]