The growing concerns over desertification have spurred research into technologies aimed at acquiring water from non-traditional sources such as dew, fog, and water vapor. Some of the most promising developments have focused on improving designs to collect water from fog. However, the absence of a shared framework to predict, measure and compare the water collection efficiencies of new prototypes is becoming a major obstacle to progress in the field. We address this problem by providing a general theory to design efficient fog collectors as well as a concrete experimental protocol to supply our theory with the parameters necessary to quantify the effective water collection efficiency. We show in particular that multi-layer collectors are required for high fog collection efficiency and that all efficient designs are found within a narrow range of mesh porosity. We support our conclusions with measurements on simple multi-layer harp collectors.