Fine-tuning ALK1 linear polyubiquitination to control angiogenesis
Journal: 2021/July - Trends in Cell Biology
PUBMED: 34330579
Abstract:
Editing linear polyubiquitination of protein substrates by LUBAC and OTULIN is known to play a critical role in immune responses. A recent study by Fu et al. reveals how reversible linear polyubiquitination of the activin receptor-like kinase (ALK1) controls developmental angiogenesis and how its dysfunction leads to vascular malformations in humans.
Keywords: ALK1; BMP9; LUBAC; OTULIN; angiogenesis; arteriovenous malformation.
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