Abstract:

COVID-19 is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life-threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that SARS-CoV-2 infection directly causes a deficiency in C1 esterase inhibitor (C1-INH), a pathogen-specific mechanism that may help explain significant systemic abnormalities in COVID-19 patients.

Open in

PUBMED | DOI | Google Scholar | Wikipedia

Relations:

Content

Citations

(7)

Diseases

(1)

Organisms

(1)

C1‐INH and the contact system in COVID‐19

^{Barcelona Institute for Molecular Biology, National Science Council (IBMB‐CSIC), Barcelona Spain,}

^{Networked Center for Hepatic and Digestive Diseases (CIBER‐EHD), Instituto Nacional de la Salud Carlos III, Madrid Spain,}

^{Vall d’Hebrón Institute of Research, Barcelona Spain,}

^{Clinical Biochemistry Service, Vall d’Hebrón Hospital, Barcelona Spain,}

Timothy M Thomson, Email: se.cisc.bmbi@cmbtit.

^{Corresponding author.}

^{Correspondence: Timothy M. Thomson, MD, PhD. IBMB‐CSIC, Barcelona, Spain}
E‐mail: se.cisc.bmbi@cmbtit,

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

Collaboration tool especially designed for Life Science professionals.Drag-and-drop any entity to your messages.

Learn More