Tissue factor-factor VIIa signaling.
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Journal: 2005/August - Arteriosclerosis, Thrombosis, and Vascular Biology
ISSN: 1524-4636
Abstract:
How does tissue factor (TF), whose principle role is to support clotting factor VIIa (FVIIa) in triggering the coagulation cascade, affect various pathophysiological processes? One of the answers is that TF interaction with FVIIa not only initiates clotting but also induces cell signaling via activation of G-protein-coupled protease activated receptors (PARs). Recent studies using various cell model systems and limited in vivo systems are beginning to define how TF-VIIa-induced signaling regulates cellular behavior. Signaling pathways initiated by both TF-VIIa protease activation of PARs and phosphorylation of the TF-cytoplasmic domain appear to regulate cellular functions. In the present article, we review the emerging data on the mechanism of TF-mediated cell signaling and how it regulates various cellular responses, with particular focus on TF-VIIa protease-dependent signaling.
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Arterioscler Thromb Vasc Biol 25(1): 47-56
PMID: 15569823

Tissue Factor–Factor VIIa Signaling

Biomedical Research Division, The University of Texas Health Center at Tyler, Tex
Correspondence to L. Vijaya Mohan Rao, PhD, Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708. ude.tchtu@oar.yajiv
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Abstract

How does tissue factor (TF), whose principle role is to support clotting factor VIIa (FVIIa) in triggering the coagulation cascade, affect various pathophysiological processes? One of the answers is that TF interaction with FVIIa not only initiates clotting but also induces cell signaling via activation of G-protein–coupled protease activated receptors (PARs). Recent studies using various cell model systems and limited in vivo systems are beginning to define how TF–VIIa-induced signaling regulates cellular behavior. Signaling pathways initiated by both TF–VIIa protease activation of PARs and phosphorylation of the TF–cytoplasmic domain appear to regulate cellular functions. In the present article, we review the emerging data on the mechanism of TF-mediated cell signaling and how it regulates various cellular responses, with particular focus on TF–VIIa protease-dependent signaling.

Keywords: tissue factor, factor VIIa, protease activated receptors, cell signaling
Abstract

The close link between coagulation and various diseases, such as sepsis, atherosclerosis, and tumor metastasis, suggests a complex interplay between the clotting cascade and disease progression. Numerous studies have demonstrated that coagulation proteases can function like hormones to regulate cellular behavior. For example, thrombin, the principal protease generated during coagulation, has been shown to activate platelets and regulate the behavior of other cells by transmitting signals via activation of G protein-coupled protease activated receptors (PARs). Although there has been initial skepticism on whether other clotting proteases can also activate PARs, recent studies provide convincing evidence that many proteases involved in clotting can indeed activate PARs and regulate cellular behaviors at physiological concentrations. One such protease, FVIIa, the physiological initiator of the coagulation cascade, has received much attention lately. The focus of the present article is to review briefly recent developments in tissue factor (TF)–VIIa proteolytic activity-mediated cell signaling.

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