Br Med J 4(5994): 437-439
Thyroid hormones in the elderly sick: "T4 euthyroidism".
Abstract
Thyroid function and serum levels of triiodothyronine (T3) and thyroxine (T4) were investigated in 79 euthyroid geriatric patients. Of the 59 inpatients and 20 outpatients 35 (59%) and 2, respectively, had low T3 levels. In contrast, 7 (12%) and 6 (30%), respectively, had raised T4 levels. Two further patients were excluded from the study because of raised levels of thyroid-stimulating hormone. Thyroxine-binding globulin was greatly increased in both groups of patients, but low serum albumin levels were present in 31 (39%). Despite these changes free T3 and T4 indices closely followed total T3 and T4 levels. The difference between the two groups of patients did not correlate with body weight, diagnostic categories, age, drug treatment, or duration of stay in hospital.
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- Carter JN, Eastman CJ, Corcoran JM, Lazarus L. Effect of severe, chronic illness on thyroid function. Lancet. 1974 Oct 26;2(7887):971–974. [PubMed] [Google Scholar]
- Jefferys PM, Farran HE, Hoffenberg R, Fraser PM, Hodkinson HM. Thyroid-function tests in the elderly. Lancet. 1972 Apr 29;1(7757):924–927. [PubMed] [Google Scholar]
- Thomson JA, Andrews GR, Caird FI, Wilson R. Serum protein-bound and plasma in organic iodine in the elderly at home. Age Ageing. 1972 Aug;1(3):158–161. [PubMed] [Google Scholar]
- Bahemuka M, Hodkinson HM. Screening for hypothyroidism in elderly inpatients. Br Med J. 1975 Jun 14;2(5971):601–603.[PMC free article] [PubMed] [Google Scholar]
- Burke CW, Shakespear RA. Rapid purification of tri-iodothyronine and thyroxine protein conjugates for antibody production. J Endocrinol. 1975 Apr;65(1):133–138. [PubMed] [Google Scholar]
- Hall R, Smith BR, Mukhtar ED. Thyroid stimulators in health and disease. Clin Endocrinol (Oxf) 1975 Mar;4(2):213–230. [PubMed] [Google Scholar]
- Dingle PR, Ferguson A, Horn DB, Tubmen J, Hall R. The incidence of thyroglobulin antibodies and thyroid enlargement in a general practice in north-east England. Clin Exp Immunol. 1966 Jul;1(3):277–284.[PMC free article] [PubMed] [Google Scholar]
- Rubenstein HA, Butler VP, Jr, Werner SC. Progressive decrease in serum triiodothyronine concentrations with human aging: radioimmunoassay following extraction of serum. J Clin Endocrinol Metab. 1973 Aug;37(2):247–253. [PubMed] [Google Scholar]
- Snyder PJ, Utiger RD. Response to thyrotropin releasing hormone (TRH) in normal man. J Clin Endocrinol Metab. 1972 Feb;34(2):380–385. [PubMed] [Google Scholar]
- Snyder PJ, Utiger RD. Thyrotropin response to thyrotropin releasing hormone in normal females over forty. J Clin Endocrinol Metab. 1972 Jun;34(6):1096–1098. [PubMed] [Google Scholar]
- Braverman LW, Dawber NA, Ingbar SH. Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages. J Clin Invest. 1966 Aug;45(8):1273–1279.[PMC free article] [PubMed] [Google Scholar]
- Spaulding SW, Gregerman RI. Free thyroxine in serum by equilibrium dialysis: effects of dilution, specific ions and inhibitors of binding. J Clin Endocrinol Metab. 1972 Jun;34(6):974–982. [PubMed] [Google Scholar]
- GREGERMAN RI, GAFFNEY GW, SHOCK NW, CROWDER SE. Thyroxine turnover in euthyroid man with special reference to changes with age. J Clin Invest. 1962 Nov;41:2065–2074.[PMC free article] [PubMed] [Google Scholar]