20 patients with vegetative crises (panic attacks) and 20 patients with tension-type headache were treated by Lerivon (tetracyclic antidepressant) administration. The following parameters were investigated: the degree of headache expression according to visual analogous scale, the vegetative crises frequency and depression gravity by means of Spilberg test, the depression intensity by means of Back scale. The areas of different components of contingent negative deviation (CND)-early, late, postimperative negative waves as well as total CND area-were examined either. Both high clinical effects of the preparation and normalisation of psychophysiological parameters were found. 30 mg was the common daily dose for the patients with psychophysiological disorders. The clinical effect was observed quickly (7-10 days). The patients tolerated drug administration well, the sleepiness was the only side-effect. Thus, Lerivon proved highly effective for the treatment of both psychovegetative and algesic disorders and had some advantages as compared with commonly used tricyclic antidepressants.