The development of <em>Terminalia chebula</em> Retz. (Combretaceae) in clinical research

*Corresponding author: Rabi Ranjan Chattopadhyay, Agricultural and Ecological Research Unit, Indian Statistical Institute 203, Barrackpore Trunk Road Kolkata-700 108, India. Tel: +91-33-2575 3275, Fax: +91-33-2577 3049, E-mail: ni.ca.lacisi@ibar; moc.liamg@yayhdapottahc.ibar

Received 2013 Jan 15; Accepted 2013 Feb 26.

Abstract

Medicinal plants are part and parcel of human society to combat diseases from the dawn of civilization. Terminalia chebula Retz. (Fam. Combretaceae), is called the ‘King of Medicine’ in Tibet and is always listed at the top of the list of ‘Ayurvedic Materia Medica’ because of its extraordinary power of healing. The whole plant possesses high medicinal value and traditionally used for the treatment of various ailments for human beings. Some of the folklore people used this plant in the treatment of asthma, sore throat, vomiting, hiccough, diarrhea, dysentery, bleeding piles, ulcers, gout, heart and bladder diseases. The plant has been demonstrated to possess multiple pharmacological and medicinal activities, such as antioxidant, antimicrobial, antidiabetic, hepatoprotective, anti-inflammatory, antimutagenic, antiproliferative, radioprotective, cardioprotective, antiarthritic, anticaries, gastrointestinal motility and wound healing activity. But no systematic updated information on the therapeutic effectiveness of Terminalia chebula, a popular herbal remedy in India and South-East Asia has so far been reported. This review highlights an updated information particularly on the phytochemistry and various pharmacological and medicinal properties of Terminalia chebula Retz. and some of its isolated compounds, along with their safety evaluation. This may provide incentive for proper evaluation of the plant as medicinal agent against the human diseases and also to bridge the lacunae in the existing literature and future scope which may offer immense opportunity for researchers engaged in validation of the traditional claims and development of safe and effective botanical medicine.

Keywords: Terminalia chebula, Human diseases, Medicinal value, Bioactive constituents, Safety evaluation

Abstract

Acknowledgments

Authors wish to acknowledge the Head, Agricultural and Ecological Research Unit, Indian Statistical Institute, Kolkata, India for her kind help and cooperation during this work and also Prof. T. K. Basu, former Head, Biometry Research Unit, Indian Statistical Institute, Kolkata, India for critically going through the manuscript.

Acknowledgments

Notes

Comments

Background

This is a review paper on the benefits of T. chebula as an alternative medicine for many diseases. The pharmacological effects exhibited by this plant have been elaborated in depth with citations from studies that have been conducted using this Ayurvedic plant.

Research frontiers

There is no lab experiment being done in this manuscript since it is a review paper. However, the author cited latest and recent publications on works done in this particular field, in which bring the readers to the recent analytical approach for pharmacological potential of this plant.

Related reports

The author cited different papers in his manuscript to support the therapeutic potential of T. chebula in traditional medicine. Past studies mostly presented the pharmacological activities of this plant done in vitro and in vivo.

Innovations and breakthroughs

This review paper is one of its own in which it summarizes any research that have been conducted on T. chebula specifically in medicinal field. It is a good source of literature survey for researchers who intended to do studies in this particular field, and using this plant.

Applications

This paper could be applied by most Ayurvedic practitioners in their medication activities to treat patients with different types of diseases.

Peer review

This paper is a good review paper on Ayurvedic and pharmacological activities of T. chebula. Citations used are also a good resources for reviewing and very informative to all the Ayurvedic and traditional practitioners.

Notes

Footnotes

Foundation Projetct: Supported by Indian Statistical Institute, Kolkata, India (Grant No. Project A/C No. 5613).

Conflict of interest statement: We declare that we have no conflict of interest.

Footnotes

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