The Database of Interacting Proteins: 2004 update

Lukasz Salwinski

Christopher Miller

Adam Smith

Frank Pettit

James Bowie

David Eisenberg

^{Howard Hughes Medical Institute,}^{UCLA-DOE Institute for Genomics and Proteomics,}^{Department of Chemistry and Biochemistry and}^{Department of Biological Chemistry, Molecular Biology Institute, Box 951570, UCLA, Los Angeles, CA 90095-1570, USA}

^{To whom correspondence should be addressed. Tel: +1 310 825 3754; Fax: +1 310 206 3914; Email:}ude.alcu.ibm@divad

Received 2003 Sep 18; Revised 2003 Oct 6; Accepted 2003 Oct 6.

Abstract

The Database of Interacting Proteins (http://dip.doe-mbi.ucla.edu) aims to integrate the diverse body of experimental evidence on protein–protein interactions into a single, easily accessible online database. Because the reliability of experimental evidence varies widely, methods of quality assessment have been developed and utilized to identify the most reliable subset of the interactions. This CORE set can be used as a reference when evaluating the reliability of high-throughput protein–protein interaction data sets, for development of prediction methods, as well as in the studies of the properties of protein interaction networks.

Abstract

ACKNOWLEDGEMENTS

We thank the NIH and DOE for support of DIP.

ACKNOWLEDGEMENTS

REFERENCES

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