Targeting leukemic stem cells by breaking their dormancy.
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Journal: 2011/January - Molecular Oncology
ISSN: 1878-0261
Abstract:
Transient or long-term quiescence, the latter referred to as dormancy are fundamental features of at least some adult stem cells. The status of dormancy is likely a critical mechanism for the observed resistance of normal HSCs and leukemic stem cells (LSCs) to anti-proliferative chemotherapy. Recent studies have revealed cytokines such as Interferon-alpha (IFNα) and G-CSF as well as arsenic trioxide (As(2)O(3)) to be efficient agents for promoting cycling of dormant HSCs and LSCs. Most interestingly, such cell cycle activated stem cells become exquisitely sensitive to killing by different chemotherapeutic agents, suggesting that dormant LSCs in patients may be targeted by a sequential two-step protocol involving an initial activation by IFNα, G-CSF or As(2)O(3), followed by targeted chemotherapy.
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Mol Oncol 4(5): 443-450
PMID: 20599449

Targeting leukemic stem cells by breaking their dormancy

HI-STEM (Heidelberg Institute for Stem Cell Technology and Experimental Medicine), Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
Marieke Alida Gertruda Essers, Email: ed.mets-ih@sresse.ekeiram.
Corresponding author.
Corresponding author.
Received 2010 May 4; Revised 2010 Jun 1; Accepted 2010 Jun 1.
Copyright © 2010 Federation of European Biochemical Societies

Notes

Essers Marieke Alida Gertruda, Trumpp Andreas, (2010), Targeting leukemic stem cells by breaking their dormancy, Molecular Oncology, 4, doi: 10.1016/j.molonc.2010.06.001. [PMC free article] [PubMed] [Google Scholar]

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