Ochsner J 14(2): 203-207

Steroids: Pharmacology, Complications, and Practice Delivery Issues

^{Department of Anesthesiology, Ochsner Clinic Foundation, New Orleans, LA}

^{Departments of Anesthesiology and Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA}

Address correspondence to Alan David Kaye, MD, PhD, Professor and Chairman, Department of Anesthesiology, Professor, Department of Pharmacology, Louisiana State University Health Sciences Center, 1542 Tulane Ave., Room 656, New Orleans, LA 70112, Tel: (504) 568-2319, Email: ude.cshusl@eyaka

Abstract

Background

Since their identification nearly 80 years ago, steroids have played a prominent role in the treatment of many disease states. Many of the clinical roles of steroids are related to their potent antiinflammatory and immune-modulating properties.

Methods

This review summarizes the basic pharmacology, complications, and practice delivery issues regarding steroids.

Results

Clinically relevant side effects of steroids are common and problematic. Side effects can occur at a wide range of doses and vary depending on the route of administration. The full spectrum of side effects can be present even in patients taking low doses.

Conclusions

Practitioners must be aware that these drugs might exacerbate a preexisting condition or present a new medical condition. Knowledge of the clinical implications of prescribing these agents is critical.

Keywords: Adrenal cortex hormones, diabetes mellitus, drug-related side effects and adverse reactions, glucocorticoids, medication therapy management, mineralocorticoids

Abstract

Footnotes

The authors have no financial or proprietary interest in the subject matter of this article.

Footnotes

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