Rab5 and rac team up in cell motility.
Journal: 2008/July - Cell
ISSN: 1097-4172
PUBMED: 18614005
Abstract:
Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamidessi et al. (2008) show that Rab5-directed trafficking of Rac to the cell membrane is required for Rac-mediated actin assembly. Trafficking of Rac may influence the mode of cell migration during morphogenesis and cancer metastasis.
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