Polymers in small-interfering RNA delivery.
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Journal: 2011/November - Nucleic Acid Therapeutics
ISSN: 2159-3345
Abstract:
This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles. The article will provide a brief and concise account of underlying principle of these polymeric vectors and their structural and functional modifications which were intended to serve different purposes to affect efficient therapeutic outcome of small-interfering RNA delivery. The modifications of these polymeric vectors will be discussed with reference to stimuli-responsiveness, target specific delivery, and incorporation of nanoconstructs such as carbon nanotubes, gold nanoparticles, and silica nanoparticles. The emergence of small-interfering RNA as the potential therapeutic agent and its mode of action will also be mentioned in a nutshell.
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Nucleic Acid Ther 21(3): 133-147
PMID: 21749290

Polymers in Small-Interfering RNA Delivery

Department of Chemistry, BK School of Molecular Science, Polymer Research Institute, Pohang University of Science and Technology, Pohang, Korea.
Corresponding author.
Address correspondence to: Prof. Won Jong Kim, Department of Chemistry, BK School of Molecular Science, Polymer Research Institute, Pohang University of Science and Technology, San31 Hyoja, Namgu, Pohang 790-784, Korea. E-mail:rk.ca.hcetsop@mikjw
Address correspondence to: Prof. Won Jong Kim, Department of Chemistry, BK School of Molecular Science, Polymer Research Institute, Pohang University of Science and Technology, San31 Hyoja, Namgu, Pohang 790-784, Korea. E-mail:rk.ca.hcetsop@mikjw
Received 2011 Mar 7; Accepted 2011 Mar 28.
Copyright 2011, Mary Ann Liebert, Inc.

Abstract

This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles. The article will provide a brief and concise account of underlying principle of these polymeric vectors and their structural and functional modifications which were intended to serve different purposes to affect efficient therapeutic outcome of small-interfering RNA delivery. The modifications of these polymeric vectors will be discussed with reference to stimuli-responsiveness, target specific delivery, and incorporation of nanoconstructs such as carbon nanotubes, gold nanoparticles, and silica nanoparticles. The emergence of small-interfering RNA as the potential therapeutic agent and its mode of action will also be mentioned in a nutshell.

Abstract
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