The effect of two different methods of forced diuresis was investigated in two groups consisting of twelve patients. These groups were statistically selected from 86 cases with severe poisoning caused by hypnotic drugs, exhibiting a comparable metabolic and neurological symptomatology. Group 1 underwent the usual diuretic therapy group 2 was treated with standardised forced duiresis (SFD). In group 2 a significant higher hourly urinary output, a lower incidence of acidosis and more stability of the electrolyte balance were found. Therefore SFD was judged to be a useful help in elimination of hypnotic drugs.