Pin1 flips Alzheimer's switch.
Journal: 2007/January - ACS Chemical Biology
ISSN: 1554-8937
Abstract:
The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a peptidyl-prolyl isomerase, Pin1, specifically regulates the degradation of amyloid precursor protein (APP). An alternative model for Pin1 regulation of APP processing is also proposed.
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