Abstract:

Diabetes is a chronic, lifelong condition due to inadequate production of insulin or the cells does not properly respond it. Recently, the significance and effectiveness of herbal drugs associated with diabetes has emerged. The aim of the present study was to determine the anti-diabetic effects of Terminalia catappa L. leaves on streptozotocin (STZ)-treated rats. Two different concentrations of ethanolic leaf extract (300 and 500 mg/kg) of T. catappa were used to treat diabetic rats, and biochemical parameters were analyzed in blood samples. The results of herbal treatments were compared with the standard drug, glibenclamide. The ethanol extract (500 mg/kg) had significant anti-diabetic activity by altering blood glucose, glycosylated hemoglobin, liver glycogen, glucose 6-phosphatase, fructose 1,6-bisphosphatase, glucokinase, aspartate transaminase, alanine transaminase, alkaline phosphatase, urea, uric acid and creatinine levels while increasing insulin levels. Thus, the present study suggests that the supplementation of the diabetic patients with T. catappa leaves can lead to recovery from diabetic effects.

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Phytotherapeutic efficacy of the medicinal plant <em>Terminalia catappa</em> L.

Natarajan Divya

R Rengarajan

Ramalingam Radhakrishnan

^{Department of Biochemistry, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India}

^{Centre for Pheromone Technology, Department of Animal Science, Bharathidasan University, Trichirappalli, Tamil Nadu, India}

^{Department of Microbiology, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India}

^{Plant Production Department, College of Food and Agricultural Sciences, King Saud University, P.O. Box. 2460, Riyadh 11451, Saudi Arabia}

^{Botany and Microbiology Department, College of Science, King Saud University, P.O. Box. 2460, Riyadh 11451, Saudi Arabia}

^{Mycology and Plant Disease Survey Department, Plant Pathology Research Institute, ARC, Giza 12511, Egypt}

^{Department of Biochemistry, M.I.E.T Arts and Science College, Tiruchirappalli, Tamil Nadu, India}

^{Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India}

Arumugam Vijaya Anand: ni.ude.cub@bmghava

^{Corresponding author.}ni.ude.cub@bmghava

Arumugam Vijaya Anand: ni.ude.cub@bmghava

Received 2018 Jul 9; Revised 2018 Dec 11; Accepted 2018 Dec 16.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Values are means ± SD of six rats in each group;

Values are means ± SD of six rats in each group; *Significant different at p < 0.05,

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Peer review under responsibility of King Saud University.

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