Perturbation of upper gastrointestinal function by cold stress.
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Journal: 1983/May - Gut
ISSN: 0017-5749
PUBMED: 6832623
Abstract:
To study the effects of stressful stimulus (cold pain) upon postprandial gastric, duodenal, and pancreatic function, nine healthy adult volunteers were intubated and then given two identical liquid meals, (199 cal (789 KJ) 240 ml), each being ingested during a period of irregular fasting gastroduodenal motility. Ten minutes after each meal the subjects received, in randomised order, either a test or control stimulus. The test stimulus consisted of repeated one minute immersions of a hand into ice water, with 15 seconds recovery between immersions, for a total of 20 minutes, while for the control, water at 37 degrees C was used. Serial samples of gastric and duodenal contents allowed estimation of changes in gastric emptying and acid secretion, together with pancreatic trypsin output, by a double marker perfusion technique. Measurements of blood pressure, pulse, and finger temperature acted as extra-intestinal indices of autonomic response to the stimuli. Cold pain significantly delayed gastric emptying and produced a biphasic alteration in both gastric secretion and pancreatic trypsin output, with an initial reduction during the response to the stress followed by an increase during the post-stress period. Our findings show that the normal postprandial function of the upper gut can be measurably disturbed by a stressful stimulus. The coincidence of these disturbances with other extra-intestinal autonomic changes suggests that they are a further manifestation of the somatic response to a stress.
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Gut 24(4): 277-283
PMID: 6832623

Perturbation of upper gastrointestinal function by cold stress.

Abstract

To study the effects of stressful stimulus (cold pain) upon postprandial gastric, duodenal, and pancreatic function, nine healthy adult volunteers were intubated and then given two identical liquid meals, (199 cal (789 KJ) 240 ml), each being ingested during a period of irregular fasting gastroduodenal motility. Ten minutes after each meal the subjects received, in randomised order, either a test or control stimulus. The test stimulus consisted of repeated one minute immersions of a hand into ice water, with 15 seconds recovery between immersions, for a total of 20 minutes, while for the control, water at 37 degrees C was used. Serial samples of gastric and duodenal contents allowed estimation of changes in gastric emptying and acid secretion, together with pancreatic trypsin output, by a double marker perfusion technique. Measurements of blood pressure, pulse, and finger temperature acted as extra-intestinal indices of autonomic response to the stimuli. Cold pain significantly delayed gastric emptying and produced a biphasic alteration in both gastric secretion and pancreatic trypsin output, with an initial reduction during the response to the stress followed by an increase during the post-stress period. Our findings show that the normal postprandial function of the upper gut can be measurably disturbed by a stressful stimulus. The coincidence of these disturbances with other extra-intestinal autonomic changes suggests that they are a further manifestation of the somatic response to a stress.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Wolf S. The psyche and the stomach. A historical vignette. Gastroenterology. 1981 Mar;80(3):605–614. [PubMed] [Google Scholar]
  • Stanciu C, Bennett JR. The general pattern of gastro-duodenal motility: 24 hour recordings in normal subjects. Rev Med Chir Soc Med Nat Iasi. 1975 Jan-Mar;79(1):31–36. [PubMed] [Google Scholar]
  • Vantrappen G, Janssens J, Hellemans J, Ghoos Y. The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest. 1977 Jun;59(6):1158–1166.[PMC free article] [PubMed] [Google Scholar]
  • Vantrappen GR, Peeters TL, Janssens J. The secretory component of the interdigestive migrating motor complex in man. Scand J Gastroenterol. 1979;14(6):663–667. [PubMed] [Google Scholar]
  • Malagelada JR, Longstreth GF, Summerskill WH, Go VL. Measurement of gastric functions during digestion of ordinary solid meals in man. Gastroenterology. 1976 Feb;70(2):203–210. [PubMed] [Google Scholar]
  • Rees WD, Go VL, Malagelada JR. Antroduodenal motor response to solid-liquid and homogenized meals. Gastroenterology. 1979 Jun;76(6):1438–1442. [PubMed] [Google Scholar]
  • Lovallo W. The cold pressor test and autonomic function: a review and integration. Psychophysiology. 1975 May;12(3):268–282. [PubMed] [Google Scholar]
  • Reiser MF, Ferris EB., Jr THE NATURE OF THE COLD PRESSOR TEST AND ITS SIGNIFICANCE IN RELATION TO NEUROGENIC AND HUMORAL MECHANISMS IN HYPERTENSION. J Clin Invest. 1948 Jan;27(1):156–163.[PMC free article] [PubMed] [Google Scholar]
  • Arndorfer RC, Stef JJ, Dodds WJ, Linehan JH, Hogan WJ. Improved infusion system for intraluminal esophageal manometry. Gastroenterology. 1977 Jul;73(1):23–27. [PubMed] [Google Scholar]
  • Kerlin P, Phillips S. Variability of motility of the ileum and jejunum in healthy humans. Gastroenterology. 1982 Apr;82(4):694–700. [PubMed] [Google Scholar]
  • Burn-Murdoch R, Fisher MA, Hunt JN. Does lying on the right side increase the rate of gastric emptying? J Physiol. 1980 May;302:395–398.[PMC free article] [PubMed] [Google Scholar]
  • Malagelada JR, Go VL, Summerskill WH. Different gastric, pancreatic, and biliary responses to solid-liquid or homogenized meals. Dig Dis Sci. 1979 Feb;24(2):101–110. [PubMed] [Google Scholar]
  • Rees WD, Malagelada JR, Miller LJ, Go VL. Human interdigestive and postprandial gastrointestinal motor and gastrointestinal hormone patterns. Dig Dis Sci. 1982 Apr;27(4):321–329. [PubMed] [Google Scholar]
  • Schumacher GA, Goodell H, Hardy JD, Wolff HG. UNIFORMITY OF THE PAIN THRESHOLD IN MAN. Science. 1940 Aug 2;92(2379):110–112. [PubMed] [Google Scholar]
  • WOLFF HH. The mechanism and significance of the cold pressor response. Q J Med. 1951 Jul;20(79):261–273. [PubMed] [Google Scholar]
  • Ulrych M. Changes of general haemodynamics during stressful mental arithmetic and non-stressing quiet conversation and modification of the latter by beta-adrenergic blockade. Clin Sci. 1969 Jun;36(3):453–461. [PubMed] [Google Scholar]
  • Obrist PA, Gaebelein CJ, Teller ES, Langer AW, Grignolo A, Light KC, McCubbin JA. The relationship among heart rate, caratid dP/dt, and blood pressure in humans as a function of the type of stress. Psychophysiology. 1978 Mar;15(2):102–115. [PubMed] [Google Scholar]
  • Furness JB, Costa M. The adrenergic innervation of the gastrointestinal tract. Ergeb Physiol. 1974;69(0):2–51. [PubMed] [Google Scholar]
  • Bloom SR, Edwards AV, Vaughan NJ. The role of the sympathetic innervation in the control of plasma glucagon concentration in the calf. J Physiol. 1973 Sep;233(2):457–466.[PMC free article] [PubMed] [Google Scholar]
  • Lass N, Doron O, Gilat T. Gastric acid secretion in cold urticaria. Dig Dis Sci. 1980 Jul;25(7):526–528. [PubMed] [Google Scholar]
  • Badgley LE, Spiro HM, Senay EC. Effect of mental arithmetic on gastric secretion. Psychophysiology. 1969 May;5(6):633–637. [PubMed] [Google Scholar]
  • EICHHORN R, TRACKTIR J. The effect of hypnotically induced emotions upon gastric secretion. Gastroenterology. 1955 Sep;29(3):432–438. [PubMed] [Google Scholar]
  • GOLDMAN MC. Gastric secretion during a medical interview. Psychosom Med. 1963 Jul-Aug;25:351–356. [PubMed] [Google Scholar]
  • Miller RJ, Bergeim O, Hawk PB. GASTRIC RESPONSE TO FOODS. Science. 1920 Sep 10;52(1341):253–254. [PubMed] [Google Scholar]
  • Stacher G, Berner P, Naske R, Schuster P, Stärker H, Schulze D. Effect of bromazepam on gastric acid secretion related to hypnotically induced anxiety. Int J Clin Pharmacol Biopharm. 1976 Sep;14(2):126–131. [PubMed] [Google Scholar]
  • SHAY H. Emotional stress and parietal cell mass: their role in the etiology of peptic ulcer. Am J Dig Dis. 1959 Nov;4:846–870. [PubMed] [Google Scholar]
  • FRENCH JD, LONGMIRE RL, PORTER RW, MOVIUS HJ. Extravagal influences on gastric hydrochloric acid secretion induced by stress stimuli. Surgery. 1953 Sep;34(3):621–632. [PubMed] [Google Scholar]
  • Harper AA, Vass CC. The control of the external secretion of the pancreas in cats. J Physiol. 1941 Jun 30;99(4):415–435.[PMC free article] [PubMed] [Google Scholar]
  • Guillemin R, Vargo T, Rossier J, Minick S, Ling N, Rivier C, Vale W, Bloom F. beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland. Science. 1977 Sep 30;197(4311):1367–1369. [PubMed] [Google Scholar]
  • Feldman M, Walsh JH, Taylor IL. Effect of naloxone and morphine on gastric acid secretion and on serum gastrin and pancreatic polypeptide concentrations in humans. Gastroenterology. 1980 Aug;79(2):294–298. [PubMed] [Google Scholar]
  • Yamaguchi I. A comparative study on the mechanism of action of morphine on gastric acid secretion in dogs. Jpn J Pharmacol. 1974 Oct;24(5):779–786. [PubMed] [Google Scholar]
  • Konturek SJ, Tasler J, Cieszkowski M, Mikoś E, Coy DH, Schally AV. Comparison of methionine-enkephalin and morphine in the stimulation of gastric acid secretion in the dog. Gastroenterology. 1980 Feb;78(2):294–300. [PubMed] [Google Scholar]
  • Konturek SJ, Tasler J, Cieszkowski M, Jaworek J, Coy DH, Schally AV. Inhibition of pancreatic secretion by enkephalin and morphine in dogs. Gastroenterology. 1978 May;74(5 Pt 1):851–855. [PubMed] [Google Scholar]
Copyright notice
Abstract
To study the effects of stressful stimulus (cold pain) upon postprandial gastric, duodenal, and pancreatic function, nine healthy adult volunteers were intubated and then given two identical liquid meals, (199 cal (789 KJ) 240 ml), each being ingested during a period of irregular fasting gastroduodenal motility. Ten minutes after each meal the subjects received, in randomised order, either a test or control stimulus. The test stimulus consisted of repeated one minute immersions of a hand into ice water, with 15 seconds recovery between immersions, for a total of 20 minutes, while for the control, water at 37 degrees C was used. Serial samples of gastric and duodenal contents allowed estimation of changes in gastric emptying and acid secretion, together with pancreatic trypsin output, by a double marker perfusion technique. Measurements of blood pressure, pulse, and finger temperature acted as extra-intestinal indices of autonomic response to the stimuli. Cold pain significantly delayed gastric emptying and produced a biphasic alteration in both gastric secretion and pancreatic trypsin output, with an initial reduction during the response to the stress followed by an increase during the post-stress period. Our findings show that the normal postprandial function of the upper gut can be measurably disturbed by a stressful stimulus. The coincidence of these disturbances with other extra-intestinal autonomic changes suggests that they are a further manifestation of the somatic response to a stress.
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