J Clin Invest 52(1): 181-184
Parathyroid Function in Primary Osteoporosis
Abstract
Two major species of serum immunoreactive parathyroid hormone (iPTH) were measured in 47 untreated patients with primary osteoporosis by using two highly specific radioimmunoassays. Mean iPTH was normal with one antiserum but was lower than normal (P < 0.001) with the other, iPTH values did not correlate with biochemical parameters or with the proportion of bone-resorbing surfaces in iliac crest bone biopsy specimens. These data suggest that the increased bone resorption is not due to increased parathyroid function in most osteoporotic patients. However, seven of our patients (15%) appear to represent a separate population because they had increased values with one or the other of the antisera.
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- JOWSEY J, PHIL D, KELLY PJ, RIGGS BL, BIANCO AJ, Jr, SCHOLZ DA, GERSHON-COHEN J. QUANTITATIVE MICRORADIOGRAPHIC STUDIES OF NORMAL AND OSTEOPOROTIC BONE. J Bone Joint Surg Am. 1965 Jun;47:785–806. [PubMed] [Google Scholar]
- Wu K, Jett S, Frost HM. Bone resorption rates in rib in physiological, senile, and postmenopausal osteoporoses. J Lab Clin Med. 1967 May;69(5):810–818. [PubMed] [Google Scholar]
- Hossain M, Smith DA, Nordin BE. Parathyroid activity and postmenopausal osteoporosis. Lancet. 1970 Apr 18;1(7651):809–811. [PubMed] [Google Scholar]
- Nordin BE. Clinical significance and pathogenesis of osteoporosis. Br Med J. 1971 Mar 13;1(5749):571–576.[PMC free article] [PubMed] [Google Scholar]
- Jowsey J, Balasubramaniam P. Effect of phosphate supplements on soft-tissue calcification and bone turnover. Clin Sci. 1972 Mar;42(3):289–299. [PubMed] [Google Scholar]
- Arnaud CD, Tsao HS, Littledike T. Radioimmunoassay of human parathyroid hormone in serum. J Clin Invest. 1971 Jan;50(1):21–34.[PMC free article] [PubMed] [Google Scholar]
- CAMERON JR, SORENSON J. MEASUREMENT OF BONE MINERAL IN VIVO: AN IMPROVED METHOD. Science. 1963 Oct 11;142(3589):230–232. [PubMed] [Google Scholar]
- Arnaud CD, Tsao HS, Oldham SB. Native human parathyroid hormone: an immunochemical investigation. Proc Natl Acad Sci U S A. 1970 Sep;67(1):415–422.[PMC free article] [PubMed] [Google Scholar]
- Arnaud CD, Sizemore GW, Oldham SB, Fischer JA, Tsao HS, Littledike ET. Human parathyroid hormone: glandular and secreted molecular species. Am J Med. 1971 May;50(5):630–638. [PubMed] [Google Scholar]
- Canterbury JM, Reiss E. Fractionation of circulating parathyroid hormone (PTH) in man. J Lab Clin Med. 1971 Nov;78(5):814–814. [PubMed] [Google Scholar]
- Habener JF, Powell D, Murray TM, Mayer GP, Potts JT., Jr Parathyroid hormone: secretion and metabolism in vivo. Proc Natl Acad Sci U S A. 1971 Dec;68(12):2986–2991.[PMC free article] [PubMed] [Google Scholar]
- Jowsey J, Riggs BL, Goldsmith RS, Kelly PJ, Arnaud CD. Effects of prolonged administration of porcine calcitonin in postmenopausal osteoporosis. J Clin Endocrinol Metab. 1971 Nov;33(5):752–758. [PubMed] [Google Scholar]
- Kelly PJ, Jowsey J, Riggs BL, Elveback LR. Relationship between serum phosphate concentration and bone resorption in osteoporosis. J Lab Clin Med. 1967 Jan;69(1):110–115. [PubMed] [Google Scholar]