Osteoporosis in patients with inflammatory bowel disease.
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Journal: 1987/July - Gut
ISSN: 0017-5749
PUBMED: 3583068
Abstract:
Bone mineral content in spinal trabecular and peripheral cortical bone was measured in 75 unselected patients with small and/or large intestinal inflammatory bowel disease. Osteoporosis, defined as a bone mineral content greater than 2 SD below the age and sex matched normal mean value was present in 23 patients (30.6%). Three amenorrhoeic females aged 34, 38, and 42 years had severe clinical osteoporosis and a further three patients had one or more vertebral crush fractures. Eighteen of the 23 patients with osteoporosis had small intestinal disease with one or more resections and the mean lifetime steroid dose in those with osteoporosis was significantly higher than in those with normal bone mineral content. Bone mineral content in spinal trabecular bone showed significant negative correlations with lifetime steroid dose and serum alkaline phosphatase and a significant positive correlation with serum albumin. Peripheral cortical bone mineral content was positively correlated with body weight, height and body mass index. We conclude that the prevalence of osteoporosis is increased in patients with inflammatory bowel disease, severe clinical osteoporosis developing in some relatively young patients. The pathogenesis of this bone loss is probably multifactorial; steroid therapy is likely to be an important contributory factor.
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Gut 28(4): 410-415
PMID: 3583068

Osteoporosis in patients with inflammatory bowel disease.

Abstract

Bone mineral content in spinal trabecular and peripheral cortical bone was measured in 75 unselected patients with small and/or large intestinal inflammatory bowel disease. Osteoporosis, defined as a bone mineral content greater than 2 SD below the age and sex matched normal mean value was present in 23 patients (30.6%). Three amenorrhoeic females aged 34, 38, and 42 years had severe clinical osteoporosis and a further three patients had one or more vertebral crush fractures. Eighteen of the 23 patients with osteoporosis had small intestinal disease with one or more resections and the mean lifetime steroid dose in those with osteoporosis was significantly higher than in those with normal bone mineral content. Bone mineral content in spinal trabecular bone showed significant negative correlations with lifetime steroid dose and serum alkaline phosphatase and a significant positive correlation with serum albumin. Peripheral cortical bone mineral content was positively correlated with body weight, height and body mass index. We conclude that the prevalence of osteoporosis is increased in patients with inflammatory bowel disease, severe clinical osteoporosis developing in some relatively young patients. The pathogenesis of this bone loss is probably multifactorial; steroid therapy is likely to be an important contributory factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • SALVESEN HA, BOE J. Osteomalacia in sprue. Acta Med Scand. 1953;146(4):290–299. [PubMed] [Google Scholar]
  • NORDIN BE. Effect of malabsorption syndrome on calcium metabolism. Proc R Soc Med. 1961 Jun;54:497–500.[PMC free article] [PubMed] [Google Scholar]
  • Genant HK, Mall JC, Wagonfeld JB, Horst JV, Lanzi LH. Skeletal demineralization and growth retardation in inflammatory bowel disease. Invest Radiol. 1976 Nov-Dec;11(6):541–549. [PubMed] [Google Scholar]
  • Hylander E, Ladefoged K, Madsen S. Calcium balance and bone mineral content following small-intestinal resection. Scand J Gastroenterol. 1981;16(2):167–176. [PubMed] [Google Scholar]
  • Hahn TJ, Boisseau VC, Avioli LV. Effect of chronic corticosteroid administration on diaphyseal and metaphyseal bone mass. J Clin Endocrinol Metab. 1974 Aug;39(2):274–282. [PubMed] [Google Scholar]
  • Bullamore JR, Wilkinson R, Gallagher JC, Nordin BE, Marshall DH. Effect of age on calcium absorption. Lancet. 1970 Sep 12;2(7672):535–537. [PubMed] [Google Scholar]
  • Parfitt AM, Gallagher JC, Heaney RP, Johnston CC, Neer R, Whedon GD. Vitamin D and bone health in the elderly. Am J Clin Nutr. 1982 Nov;36(5 Suppl):1014–1031. [PubMed] [Google Scholar]
  • Aitken JM, Hart DM, Lindsay R. Oestrogen replacement therapy for prevention of osteoporosis after oophorectomy. Br Med J. 1973 Sep 8;3(5879):515–518.[PMC free article] [PubMed] [Google Scholar]
  • Genant HK, Cann CE, Ettinger B, Gordan GS. Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med. 1982 Nov;97(5):699–705. [PubMed] [Google Scholar]
  • Krølner B, Pors Nielsen S. Measurement of bone mineral content (BMC) of the lumbar spine, I. Theory and application of a new two-dimensional dual-photon attenuation method. Scand J Clin Lab Invest. 1980;40(7):653–663. [PubMed] [Google Scholar]
  • Addison GM, Hales CN, Woodhead JS, O'Riordan JL. Immunoradiometric assay of parathyroid hormone. J Endocrinol. 1971 Mar;49(3):521–530. [PubMed] [Google Scholar]
  • CAMERON JR, SORENSON J. MEASUREMENT OF BONE MINERAL IN VIVO: AN IMPROVED METHOD. Science. 1963 Oct 11;142(3589):230–232. [PubMed] [Google Scholar]
  • Ringe JD, Rehpenning W, Kuhlencordt F. Physiologische Anderung des Mineralgehalts von Radius und Ulna in Abhängigkeit von Lebensalter und Geschlecht. Rofo. 1977 Apr;126(4):376–380. [PubMed] [Google Scholar]
  • Cann CE, Genant HK. Precise measurement of vertebral mineral content using computed tomography. J Comput Assist Tomogr. 1980 Aug;4(4):493–500. [PubMed] [Google Scholar]
  • Banks LM, Stevenson JC. Modified method of spinal computed tomography for trabecular bone mineral measurements. J Comput Assist Tomogr. 1986 May-Jun;10(3):463–467. [PubMed] [Google Scholar]
  • Farthing MJ, Dawson AM. Impaired semen quality in Crohn's disease--drugs, ill health, or undernutrition? Scand J Gastroenterol. 1983 Jan;18(1):57–60. [PubMed] [Google Scholar]
  • NORDIN BE. The pathogenesis of osteoporosis. Lancet. 1961 May 13;1(7185):1011–1015. [PubMed] [Google Scholar]
  • Hylander E, Ladefoged K, Jarnum S. The importance of the colon in calcium absorption following small-intestinal resection. Scand J Gastroenterol. 1980;15(1):55–60. [PubMed] [Google Scholar]
  • Southgate DA, Widdowson EM, Smits BJ, Cooke WT, Walker CH, Mathers NP. Absorption and excretion of calcium and fat by young infants. Lancet. 1969 Mar 8;1(7593):487–489. [PubMed] [Google Scholar]
  • Compston JE, Creamer B. Plasma levels and intestinal absorption of 25-hydroxyvitamin D in patients with small bowel resection. Gut. 1977 Mar;18(3):171–175.[PMC free article] [PubMed] [Google Scholar]
  • Declercq SS, Meredith PC, Rosenthal AR. Experimental siderosis in the rabbit: correlation between electroretinography and histopathology. Arch Ophthalmol. 1977 Jun;95(6):1051–1058. [PubMed] [Google Scholar]
  • Harries AD, Brown R, Heatley RV, Williams LA, Woodhead S, Rhodes J. Vitamin D status in Crohn's disease: association with nutrition and disease activity. Gut. 1985 Nov;26(11):1197–1203.[PMC free article] [PubMed] [Google Scholar]
  • Jensen GF, Christiansen C, Boesen J, Hegedüs V, Transbøl I. Relationship between bone mineral content and frequency of postmenopausal fractures. Acta Med Scand. 1983;213(1):61–63. [PubMed] [Google Scholar]
  • Hendriksen C, Kreiner S, Binder V. Long term prognosis in ulcerative colitis--based on results from a regional patient group from the county of Copenhagen. Gut. 1985 Feb;26(2):158–163.[PMC free article] [PubMed] [Google Scholar]
  • Cann CE, Genant HK, Kolb FO, Ettinger B. Quantitative computed tomography for prediction of vertebral fracture risk. Bone. 1985;6(1):1–7. [PubMed] [Google Scholar]
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Abstract
Bone mineral content in spinal trabecular and peripheral cortical bone was measured in 75 unselected patients with small and/or large intestinal inflammatory bowel disease. Osteoporosis, defined as a bone mineral content greater than 2 SD below the age and sex matched normal mean value was present in 23 patients (30.6%). Three amenorrhoeic females aged 34, 38, and 42 years had severe clinical osteoporosis and a further three patients had one or more vertebral crush fractures. Eighteen of the 23 patients with osteoporosis had small intestinal disease with one or more resections and the mean lifetime steroid dose in those with osteoporosis was significantly higher than in those with normal bone mineral content. Bone mineral content in spinal trabecular bone showed significant negative correlations with lifetime steroid dose and serum alkaline phosphatase and a significant positive correlation with serum albumin. Peripheral cortical bone mineral content was positively correlated with body weight, height and body mass index. We conclude that the prevalence of osteoporosis is increased in patients with inflammatory bowel disease, severe clinical osteoporosis developing in some relatively young patients. The pathogenesis of this bone loss is probably multifactorial; steroid therapy is likely to be an important contributory factor.
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