Nature of histamine receptors in the emetic chemoreceptor trigger zone.
Abstract
1 The protective effects of the intracerebroventicular (i.c.v.) administration of the H1-receptor antagonist, mepyramine and the H2-receptor antagonists, burimamide and metiamide on centrally induced histamine-emesis were studied in unanaesthetized dogs. 2 The PD50 values of intraventricular mepyramine, burimamide and metiamide against the 100% emetic dose of histamine (3.0 mg i.c.v.) were found to be approximately 200 mug, 20 mug and 20 mug respectively. 3 Although burimamide (i.c.v. or i.v.) afforded protection against histamine-induced emesis, there was no protection against intravenous apomorphine-or oral copper sulphate-induced emesis. 4 The results suggest that both H1- and H2-histamine receptors in the emetic chemoreceptor trigger zone of the area postrema are concerned in histamine-induced emesis.
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- Bhargava KP, Dixit KS. Role of the chemoreceptor trigger zone in histamine-induced emesis. Br J Pharmacol. 1968 Nov;34(3):508–513.[PMC free article] [PubMed] [Google Scholar]
- BHARGAVA KP, GUPTA PC, CHANDRA OM. Effect of ablation of the chemoreceptor trigger zone (CT zone) on the emetic response to intraventricular injection of apomorphine and emetine in the dog. J Pharmacol Exp Ther. 1961 Dec;134:329–331. [PubMed] [Google Scholar]
- Black JW, Duncan WA, Durant CJ, Ganellin CR, Parsons EM. Definition and antagonism of histamine H 2 -receptors. Nature. 1972 Apr 21;236(5347):385–390. [PubMed] [Google Scholar]
- BORISON HL, WANG SC. Physiology and pharmacology of vomiting. Pharmacol Rev. 1953 Jun;5(2):193–230. [PubMed] [Google Scholar]
- BRIZZEE KR, NEAL LM. A re-evaluation of the cellular morphology of the area postrema in view of recent evidence for a chemoreceptor function. J Comp Neurol. 1954 Feb;100(1):41–61. [PubMed] [Google Scholar]
- HALPERN BN, NEVEU T, WILSON CW. The distribution and fate of radioactive histamine in the rat. J Physiol. 1959 Oct;147:437–449.[PMC free article] [PubMed] [Google Scholar]
- Peng MT, Pi WP. Emesis in horse serum anaphylactic shock in dogs. Am J Physiol. 1967 Jan;212(1):131–134. [PubMed] [Google Scholar]