Mucosal Chemokines.
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Journal: 2017/March - Journal of Interferon and Cytokine Research
ISSN: 1557-7465
Abstract:
Several chemokines have important functions in mucosal immunity. While there are many chemokines, 4 of them (CCL25, CCL28, CXCL14, and CXCL17) are especially important in mucosal immunity because they are homeostatically expressed in mucosal tissues. Of these, only CCL25 and CCL28 have been widely recognized as mucosal chemokines. In this study, we review the physiology of these chemokines with specific emphasis on their function in mucosal immunity. CCL25 recruits certain important subsets of T cells that express CCR9 to the small intestine. These CCR9+ T cells also express the integrin α4β7 and have been shown to play important roles in the control of intestinal inflammation. CCL28 recruits CCR10+ IgA plasmablasts to the lactating mammary gland. The role of CXCL14 in mucosal immunity is less well defined, but a Cxcl14-/- mouse exhibits significant metabolic abnormalities. Finally, CXCL17 was the last chemokine to be described and signals through a new chemokine receptor (GPR35/CXCR8), which is expressed in a subset of macrophages that are recruited to mucosal tissues by this chemokine. We conclude that these 4 chemokines play very important roles in mucosal immunity and their continued functional characterization will likely identify novel therapeutic targets.
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J Interferon Cytokine Res 37(2): 62-70
PMID: 28207301

Mucosal Chemokines

Department of Physiology and Biophysics, Institute of Immunology, University of California, Irvine, Irvine, California.
Corresponding author.
Address correspondence to:, Dr. Albert Zlotnik, 3034 Hewitt Hall, Physiology and Biophysics, Institute for Immunology, University of California, Irvine, Irvine, CA 92697, E-mail:ude.icu@kintolza
Address correspondence to:, Dr. Albert Zlotnik, 3034 Hewitt Hall, Physiology and Biophysics, Institute for Immunology, University of California, Irvine, Irvine, CA 92697, E-mail:ude.icu@kintolza
Received 2016 Aug 15; Accepted 2016 Dec 14.
Copyright 2017, Mary Ann Liebert, Inc.

Abstract

Several chemokines have important functions in mucosal immunity. While there are many chemokines, 4 of them (CCL25, CCL28, CXCL14, and CXCL17) are especially important in mucosal immunity because they are homeostatically expressed in mucosal tissues. Of these, only CCL25 and CCL28 have been widely recognized as mucosal chemokines. In this study, we review the physiology of these chemokines with specific emphasis on their function in mucosal immunity. CCL25 recruits certain important subsets of T cells that express CCR9 to the small intestine. These CCR9 T cells also express the integrin α4β7 and have been shown to play important roles in the control of intestinal inflammation. CCL28 recruits CCR10 IgA plasmablasts to the lactating mammary gland. The role of CXCL14 in mucosal immunity is less well defined, but a Cxcl14−/− mouse exhibits significant metabolic abnormalities. Finally, CXCL17 was the last chemokine to be described and signals through a new chemokine receptor (GPR35/CXCR8), which is expressed in a subset of macrophages that are recruited to mucosal tissues by this chemokine. We conclude that these 4 chemokines play very important roles in mucosal immunity and their continued functional characterization will likely identify novel therapeutic targets.

Keywords: : Mucosa, chemokines, CCL25, CCL28, CXCL14, CXCL17
Abstract
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