The tumor suppressor p53 and the prolyl isomerase Pin1 are both highly connected proteins, lying at the crossroads between many signaling pathways that control cell proliferation and transformation. By catalyzing conformational changes in a large number of phosphorylated proteins, Pin1 has been implicated in the regulation of major cellular events, such as cell cycle progression, transcription, proliferation and differentiation. Recently, a role for Pin1 has emerged also in the DNA damage response, through modulation of p53 functions upon genotoxic stress. A further level of control has now been unveiled by showing that also the p53 sibling p73 requires Pin1 for its apoptotic activity.