Abstract:

Several antiviral compounds for HBV have been identified from traditionally used medicinal plants. We have earlier described the immune modulation properties of P. pinnata, a traditionally used Indian medicinal plant. Therefore, it is of interest to explore the anti-Hepatitis B virus activity of P. pinnata extracts by in-vitro screening assays. This study clearly demonstrated that the 5mg/ml concentration of the aqueous extract significantly inhibited the virus binding. Further, the spectral study was carried out for finding active compounds. The active chalcone derivatives namely, glabaarachalcone, and isopongachromene were isolated from P. pinnata aqueous seed extracts by standard spectral procedures. Virtual screening data shows that glabaarachalcone, and isopongachromene bound with HBV DNA polymerase protein target.

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Inhibition studies of HBV DNA polymerase using seed extracts of Pongamia pinnata

Manikannan Mathayan

Selvaraj Jayaraman

Langeswaran Kulanthaivel

Arumugam Suresh

^{Centre for Drug Discovery and Development, Col. Dr.Jeppiaar Research Park, Sathyabama Institute of Science and Technology, Chennai}

^{Department of Biochemistry, Saveetha Dental College and Hospital, Chennai 77}

^{Department of Bioinformatics, Science Campus, Alagappa University, Karaikudi}

^{Arumugam Suresh}moc.oohay@hserus_mpk

Received 2019 Jun 14; Accepted 2019 Jun 16.

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.

Abstract

Several antiviral compounds for HBV have been identified from traditionally used medicinal plants. We have earlier described the immune modulation properties of P. pinnata, a traditionally used Indian medicinal plant. Therefore, it is of interest to explore the anti-Hepatitis B virus activity of P. pinnata extracts by in-vitro screening assays. This study clearly demonstrated that the 5mg/ml concentration of the aqueous extract significantly inhibited the virus binding. Further, the spectral study was carried out for finding active compounds. The active chalcone derivatives namely, glabaarachalcone, and isopongachromene were isolated from P. pinnata aqueous seed extracts by standard spectral procedures. Virtual screening data shows that glabaarachalcone, and isopongachromene bound with HBV DNA polymerase protein target.

Keywords: DNA, HBV, polymerase, Pongamia pinnata

Abstract

Edited by P Kangueane

Citation: Mathayan et al. Bioinformation 15(7):506-512 (2019)

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