The (14)N(rho, alpha)(11)C reaction on N(2)-O(2) or N(2)-H(2) gaseous systems as targets in proton bombardment allows for the production of [(11)C]CO(2) and [(11)C]CH(4.) We report the target production of [(11)C]CH(4) and the gas phase iodination to produce [(11)C]CH(3)I with high specific radioactivity (SA). SA was calculated for four different radiopharmaceuticals produced in-house from both target produced [(11)C]CO(2) and [(11)C]CH(4.) For [(11)C]raclopride we obtained an average SA of 3908 GBq/mumol (106000 Ci/mmol) at the end of bombardment for the last 52 productions, which is a 32-fold increase compared to when using the in-house [(11)C]CO(2) target.